Ahmet Ata Özçimen | Mersin Üniversitesi

HEALTH & SCIENCE 2025-IV

YAŞAR KEVSER | ÖZÇİMEN AHMET ATA

MOLECULAR BASIS OF ANGIOGENESIS AND METASTASIS IN CANCER

Kitap Bölümü 2025 EFE AKADEMİ YAYINLARI 5 | 0

Association between serum cytokine levels with pulp necrosis and apical periodontitis in sickle cell disease

Özçimen Ahmet Ata | Ünal Selma | Yılmaz Melis | Aksu, Seçkin | Karahan Feryal

This study’s objective was to assess the relationship between serum cytokine levels and the occurrence of pulp necrosis (PN) and apical periodontitis (AP) in adolescents with Sickle Cell Disease (SCD). A total of 52 adolescents, including 29 individuals diagnosed with SCD, participated in the study. Serum cytokine levels including IL-1, IL-2, IL-4, IL-6, IL-1β, IL-8, IL-10, IL-17, and TNF-α were analyzed. Radiological and intraoral dental examinations were conducted on the same day. Electric pulp testing and cold tests were conducted on all intact crowned teeth to assess the presence of PN. Periapical index scores were derived from panoramic and periapical radiographs to identify teeth exhibiting AP. Statistical analyses were carried out using Student’s t-test, Chi-square test, Spearman correlation test, and the Mann–Whitney U test. In the SCD group, the levels of IL-2, IL-4, IL-6, IL-8, IL-17, and TNF-α were significantly higher compared to the control group (p < 0.001, < 0.001, < 0.001, < 0.001, < 0.001, and = 0.003, respectively). No statistically significant association was observed between the groups and PN status (p = 0.06). Among individuals with SCD, IL-8 and TNF-α levels were significantly higher in those with apical periodontitis (AP+) compared to those with...

Makale 2025 Scientific Reports 2 | 0

Association between serum cytokine levels with pulp necrosis and apical periodontitis in sickle cell disease

Özçimen Ahmet Ata | Ünal Selma | Yılmaz Melis | Karahan Feryal | Aksu, Seçkin

This study’s objective was to assess the relationship between serum cytokine levels and the occurrence of pulp necrosis (PN) and apical periodontitis (AP) in adolescents with Sickle Cell Disease (SCD). A total of 52 adolescents, including 29 individuals diagnosed with SCD, participated in the study. Serum cytokine levels including IL-1, IL-2, IL-4, IL-6, IL-1β, IL-8, IL-10, IL-17, and TNF-α were analyzed. Radiological and intraoral dental examinations were conducted on the same day. Electric pulp testing and cold tests were conducted on all intact crowned teeth to assess the presence of PN. Periapical index scores were derived from panoramic and periapical radiographs to identify teeth exhibiting AP. Statistical analyses were carried out using Student’s t-test, Chi-square test, Spearman correlation test, and the Mann–Whitney U test. In the SCD group, the levels of IL-2, IL-4, IL-6, IL-8, IL-17, and TNF-α were significantly higher compared to the control group (p < 0.001, < 0.001, < 0.001, < 0.001, < 0.001, and = 0.003, respectively). No statistically significant association was observed between the groups and PN status (p = 0.06). Among individuals with SCD, IL-8 and TNF-α levels were significantly higher in those with apical periodontitis (AP+) compared to those with...

Makale 2025 Scientific Reports 3 | 0