Aquatic toxic effect of epoxide derivatives on model organism Dapnia magna

Doğan, Ahmet | Özdemir, Birgül | Şimşek Kuş, Nermin

Since epoxides, which are found as natural products, show a wide range of biological activities, scientists have always been interested in studies on this subject. There are epoxides with very different substituents in the literature. For example, epoxides with lactone as paniculide A, amino as anticapsin, hydroxide as Eutypoxide B and Eutypoxide C are used as drugs by showing biological activity. Based on the studies in the literature, we planned to study the biological activity of molecules that do not contain amino, lactone and hydroxyl groups. For this purpose, we first performed the Diels-Alder reaction of 2,3-dimethyl-1,3-butadiene (1) with benzoquinone (2), in the next step, epoxidation reaction was targeted. Our research group previously showed that epoxide derivatives with anticancer properties effectively decrease cell viability of the ovarian cancer line (SKOV) and suppress cell migration of the line. Drugs are metabolized by the body and their metabolic residues are eliminated to aquatic systems. Therefore, it has become important to investigate the aquatic toxicity of drugs. Daphnia toxicity test is widely applied in aquatic toxicity studies. In this study, the chronic toxicity in water of the epoxide derivative 4 with six different concentration (2 nM, 5...