Ebru Ballı Ebru Ballı TIP FAKÜLTESİ TEMEL TIP BİLİMLERİ BÖLÜMÜ HİSTOLOJİ VE EMBRİYOLOJİ ANABİLİM DALI
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Investigation of the anticancer of photodynamic therapy effects by using the novel Schiff base ligand palladium complexes on human breast cancer cell line

Demirbağ, Burcu | Ballı, Ebru | Orekici Temel, Gülhan | Yılmaz, Mustafa Kemal | Değirmenci, Evren | Kibar, Deniz

Chemotherapy plays a role in many cancer therapies, including breast cancer, but due to its significant side effects, alternate treatment approaches have been investigated. One such alternative is photodynamic therapy (PDT), which employs a combination of oxygen, a photosensitizer (PS), and light of a specific wavelength. Transition metal complexes and SBL have gained interest in PDT. In this study aimed to assess the potential antitumor activity and underlying mechanism of a newly synthesized Schiff base ligand (SBL)-mediated PDT on MCF-7 cells, comparing its efficacy to cisplatin. We synthesized and characterized two novel Pd-conjugated SBL compounds (complex-1 and 2). Following the treatment of MCF-7 cells with these compounds, a light-emitting diode (LED) was utilized to deliver a light dose of 14.8 J/cm2. In MCF-7 cells, we also looked at cytotoxicity, cell death rates, and ROS levels. Results indicated a significant increase in cytotoxicity (IC50:12.5 µM) (p 

Investigation of the Anti-Cancer Effects of Photodynamic Therapy by Using the Schiff-Base Ligand Complex As Photosensitizers on Human Breast Cancer Cell Line

Burcu Demirbağ, Ebru Ballı

2024-12-17

Sıçanlarda Fluoksetin Hidroklorürün Neden Olduğu Testis Hasarında Kafeik Asit Fenetil Esterin Değerlendirilmesi

Ebru Ballı, Serap Yalın

2025-03-17