Novel fluorescent sensors based on coumarin-hydrazide-hydrazone hybrid for the detection of CN-, Co2+ and Ni2+ ions: DFT and bioimaging in living cells

Nural, Yahya

Novel coumarin-hydrazide-hydrazone hybrids, (E)-7-(diethylamino)-N '-(2-hydroxy-3-methoxybenzylidene)-2oxo-2H-chromene-3-carbohydrazide (1) and (E)-7-(diethylamino)-N '-(4-(diethylamino)-2-hydroxybenzylidene)2-oxo-2H-chromene-3-carbohydrazide (2), were synthesized and investigated their chemosensor properties. The sensors showed recognition properties of CN-, Co2+, and Ni2+ ions. After interaction with the cyanide anion, the coumarin-hydrazide-hydrazone sensors exhibited a color change visible to the naked eye, from yellow to colorless under daylight and from blue to green under UV light. The sensors exhibited a significant fluorescent enhancement response to the cyanide anion by the intramolecular charge transfer (ICT) mechanism. Furthermore, the recognition of cations was obser...