Synthesis, Antibacterial Activity and Photophysical Properties of Bis-benzamide derivatives

Bobuş Alkaya, Günseli | Efeoğlu, Çağla. | Acar, İrem | Dincer Kaya, Fadime Nazlı | Nural, Yahya

In this study, N,N’-(dodecane-1,12-diyl)bis(2,4-dichlorobenzamide) and N,N’-(dodecane-1,12-diyl)bis(4-bromobenzamide) as new bis-benzamides were synthesized by reaction of 1,12-diaminododecane and two different acyl chloride compounds in 88% and 92% yield, respectively. Their molecular structures were characterized using 1H NMR, 13C NMR and FT-IR techniques. Antibacterial activities of the synthesized compounds were screened against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 strains. Moreover, photophysical properties of the products in CH2Cl2 and CHCl3 were investigated using UV-vis spectroscopy. The compound 3a exhibited positive solvatochromism about 31 nm by increasing of solvent polarity.