Although copper is an essential element for animal organisms, its potentially toxic effects have been known for centuries. In recent years, nanoparticles, which are widely used in many fields, have been added to the sources that allow copper to participate in aquatic ecosystems. The difference between nanoparticles containing Cu, Zn, Fe, Ag, Ti, and Al ions from known metal toxicity is not clear enough yet, and the toxic effects of metal oxide nanoparticles continue to be investigated. In this study, it was aimed to compile the toxic effects of copper nanoparticles in aquatic organisms living in different trophic zones of the food chain and with different organizational levels.