Designing a selective electrochemical nanosensor based on molecularly imprinted polymer for detection of pirfenidone

In this study, an electrochemical determination of pirfenidone(PIR), an antifibrotic drug, was developed for the first time with a bare glassy carbon electrode(GCE) and a molecularly imprinted polymer(MIP)-based nanosensor. A molecularly imprinted polymer(MIP) incorporating o-phenylenediamine(o-PD), chitosan(CHIT), ionic liquid(IL), and diamond nanoparticles(DiaNPs) was utilized to modify a glassy carbon electrode(GCE), developing a stable and selective electrochemical nanosensor(MIP/CHIT@IL@DiaNPs/GCE) for PIR detection. The designed MIP/CHIT@IL@DiaNPs/GCE was characterized by electrochemical impedance spectroscopy(EIS), cyclic voltammetry(CV), scanning electron microscopy(SEM) and atomic force microscopy(AFM). The [Fe(CN)6]3−/4− redox couple was used as a probe to characterize the nanose...