Antifibrotic Treatment in Idiopathic Pulmonary Fibrosis (IPF) and Progressive Pulmonary Fibrosis (PPF): Real-World outcomes from a Single-Center study

Polat Yuluğ, Demet | Televi, Beyza | Unal, Fatma Sevval | Sucu, Damla Hazal | Balci, Yuksel | Nayci, Sibel | Ozge, Cengiz | Ozgur, Eylem Sercan

Abstract Introduction: Antifibrotic therapies are widely used in both idiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis (PPF). We aim to compare the demographic, clinical characteristics, and long-term outcomes of IPF and PPF patients on antifibrotic treatment at 6-month and 1-year follow-ups. Methods and Materials: This was a retrospective single-center cohort study. Between January 2021 and January 2025, patients who initiated antifibrotic therapy were retrospectively included. Pulmonary function tests were recorded before treatment, at baseline, and at 6-month and 1-year follow-up visits. Additionally, baseline 6-minute walk test results and radiological data were also documented. Results: A total of 117 cases were included in the study, consisting of 7...

Designing a selective electrochemical nanosensor based on molecularly imprinted polymer for detection of pirfenidone

In this study, an electrochemical determination of pirfenidone(PIR), an antifibrotic drug, was developed for the first time with a bare glassy carbon electrode(GCE) and a molecularly imprinted polymer(MIP)-based nanosensor. A molecularly imprinted polymer(MIP) incorporating o-phenylenediamine(o-PD), chitosan(CHIT), ionic liquid(IL), and diamond nanoparticles(DiaNPs) was utilized to modify a glassy carbon electrode(GCE), developing a stable and selective electrochemical nanosensor(MIP/CHIT@IL@DiaNPs/GCE) for PIR detection. The designed MIP/CHIT@IL@DiaNPs/GCE was characterized by electrochemical impedance spectroscopy(EIS), cyclic voltammetry(CV), scanning electron microscopy(SEM) and atomic force microscopy(AFM). The [Fe(CN)6]3−/4− redox couple was used as a probe to characterize the nanose...