Monoamine oxidase-A gene promoter polymorphism in female migraineurs
Erdal, Mehmet Emin
Objective: To assess whether there is a relationship between monoamine oxidase-A (MAOA) gene promoter polymorphism and migraine in female patients. Study design: A polymerase chain reaction based study in which MAOA promoter polymorphism was studied in 54 female migraineurs and 52 controls. Methods: The low (3-repeat) and high (one of 3.5, 4 or 5 repeat units) activityMAOA alleles were detected. The genotypes and allele frequencies were compared both within and between the groups. Results: The representation of both low (1/ 1) and high (2/ 2) activity genotypes were similar between the female migraineurs and controls. The allele frequencies were also similar between these groups. There was no relationship between the presence or absence of aura and MAO polymorphism. Conclusion: MAOA gene p...
Monoamine oxidase-A gene promoter polymorphism in temporomandibular joint pain and dysfunction
Erdal, Mehmet Emin | Erdal, Nurten
Objective: In this study we aimed to evaluate the relationship between temporomandibular joint pain and dysfunction (TMJPD) within the frame of monoamine oxidase-A gene (MAO-LPR) gene polymorphism. Methods: Ninety-three patients with TMJPD, and 91 healthy volunteers were included in the study. Symptom Checklist-90-Revised (SCL-90-R), Montgomery-Asberg Depression Rating Scale (MADRS), and State and Trait Anxiety Inventory tests (STAI-I and STAI-II) were applied to the patients that were diagnosed as having TMJPD according to the standard clinical examination protocol. Blood samples were taken from the patients, and the variability in the MAO-A gene was analyzed by amplification of DNA with polymerase chain reaction (PCR) for a genetic association study. Results: The analysis of allele and g...