ObjectiÕe: To find out the significance of the 5-HT2A receptor gene polymorphism in migraine. Study design: A PCR study in which 61 migraineurs and 44 healthy controls were included. Methods: The T102C polymorphism of the 5-HT2A receptor gene was studied. The results of the migraineurs and controls were compared. The relationship between the gene polymorphism and aura was also assessed. Results: The representations of the 5-HT2A genotypes were similar in migraineurs and controls Ž p)0.05. as well as in the male and female migraineurs Ž p)0.05.. The family history of migraine did not associate with 5-HT2A receptor gene polymorphism Ž p)0.05.. There was a significant relationship between the presence of CrC genotype and migraine with aura Ž ps0.02. while CrT and TrT genotypes were over repre...