Harnessing Knowledge on Very Important Pharmacogenes CYP2C9 and CYP2C19 Variation for Precision Medicine in Resource-Limited Global Conflict Zones
Barlas, İbrahim Ömer | Sezgin, Orhan
Pharmacogenomics harnesses the utility of a patient’s genome (n = 1) in decisions on which therapeutic drugs and in what amounts should be administered. Often, patients with shared ancestry present with comparable genetic profiles that predict drug response. However, populations are not static, thus, often, population mobility through migration, especially enmasse as is seen for refugees, changes the pharmacogenetic profiles of resultant populations and therefore observed responses to commonly used therapeutic drugs. For example, in the aftermath of the Syrian civil war since 2011, millions have fled their homes to neighboring countries in the Middle East. The growing permanence of refugees and mass migrations is a call to shift our focus in the life sciences community from old models of p...
Possible Association of FAS and FASLG Polymorphisms with the Risk of Idiopathic Azoospermia in Southeast Turkey
Erdal, Mehmet Emin | Ay, Özlem İzci
To investigate the association of the genetic variants of FAS/FASLG cell death pathway genes in male infertility, we genotyped the FAS - 670A/G, - 1377G/A, and FASLG - 124A/G single-nucleotide polymorphisms (SNPs) by real-time polymerase chain reaction in 108 infertile men with idiopathic azoospermia and in 125 proven fertile controls. The distribution of genotypes and alleles for SNPs at FAS - 1377G/A and FASLG - 124A/G loci were determined not to be statistically different between the case and control groups. However, the genotype frequencies of SNPs, FAS - 670AA and FAS - 670AG, were found to be significantly different between the case and control groups. Whereas the FAS - 670AA genotype might be regarded as a higher predisposition for idiopathic azoospermia, FAS - 670AG could be interp...
Association of microRNA Biogenesis Pathway Gene Variants and Alcohol Dependence Risk
Erdal, Mehmet Emin
Alcohol dependence (AD) is a neuropsychiatric disorder to which both genetic and environmental factors contribute. Especially, multiple genetic factors are promising to explain the etiology of AD. microRNAs (miRNAs) are members of a family of noncoding small RNAs, which are thought to be responsible for the altered gene expression in neuropsychiatric disorders. We hypothesized that single nucleotide polymorphisms (SNPs) in the miRNA biogenesis pathway may result in dysregulation of miRNA levels inside the cell. The aim of this study was to test an association between miRNA biogenesis gene variants and AD risk. Real-time polymerase chain reaction genotyping experiment was conducted on DNA samples from 123 alcohol-dependent patients and 135 healthy controls. We found that AGO1 rs595961 (w2 =...
Association of Synapsin III Gene with Adult Attention Deficit Hyperactivity Disorder
ERDAL, MEHMET EMİN
It was aimed to investigate the association of the synapsin III gene - 196 G> A and - 631 C>G polymorphisms that takes place in an encoding presynaptic protein, with adult attention deficit hyperactivity disorder (ADHD). One hundred thirty-nine patients having adult ADHD and 106 controls were included in the study. DNA samples were extracted from whole blood and genetic analyses were performed. A significant difference was determined between ADHD and synapsin III gene - 631 C>G polymorphism compared to the control group. No significant difference was determined between ADHD and synapsin III gene - 196 G>A polymorphism. These polymorphisms were found not to be associated with subtypes of ADHD. It is supposed that synaptic protein genes together with dopaminergic genes might have roles in th...
The Association of Olanzapine-Induced Weight Gain with Peroxisome Proliferator–Activated Receptor-g2 Pro12Ala Polymorphism in Patients with Schizophrenia
Erdal, Mehmet Emin | Barlas, İbrahim Ömer
Olanzapine is a second-generation antipsychotic that may cause weight gain and metabolic syndrome in some cases. The peroxisome proliferator–activated receptor (PPAR)-g is an important gene in the progress of type II diabetes and metabolic syndrome. In recent studies the polymorphism of the PPAR-g has been studied in type II diabetes mellitus, polycystic ovary syndrome, and insulin resistance syndrome. It is aimed to evaluate the association between polymorphism of PPAR-g gene and olanzapine-induced weight gain. Our study comprised 95 unrelated subjects who strictly met Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSMIV) criteria for schizophrenia, and all were of Turkish origin. All patients were evaluated with rating scales, and genetic analyses were performed. We ...