The Association of Olanzapine-Induced Weight Gain with Peroxisome Proliferator–Activated Receptor-g2 Pro12Ala Polymorphism in Patients with Schizophrenia
Erdal, Mehmet Emin | Barlas, İbrahim Ömer
Olanzapine is a second-generation antipsychotic that may cause weight gain and metabolic syndrome in some cases. The peroxisome proliferator–activated receptor (PPAR)-g is an important gene in the progress of type II diabetes and metabolic syndrome. In recent studies the polymorphism of the PPAR-g has been studied in type II diabetes mellitus, polycystic ovary syndrome, and insulin resistance syndrome. It is aimed to evaluate the association between polymorphism of PPAR-g gene and olanzapine-induced weight gain. Our study comprised 95 unrelated subjects who strictly met Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSMIV) criteria for schizophrenia, and all were of Turkish origin. All patients were evaluated with rating scales, and genetic analyses were performed. We ...
Association of microRNA Biogenesis Pathway Gene Variants and Alcohol Dependence Risk
Erdal, Mehmet Emin
Alcohol dependence (AD) is a neuropsychiatric disorder to which both genetic and environmental factors contribute. Especially, multiple genetic factors are promising to explain the etiology of AD. microRNAs (miRNAs) are members of a family of noncoding small RNAs, which are thought to be responsible for the altered gene expression in neuropsychiatric disorders. We hypothesized that single nucleotide polymorphisms (SNPs) in the miRNA biogenesis pathway may result in dysregulation of miRNA levels inside the cell. The aim of this study was to test an association between miRNA biogenesis gene variants and AD risk. Real-time polymerase chain reaction genotyping experiment was conducted on DNA samples from 123 alcohol-dependent patients and 135 healthy controls. We found that AGO1 rs595961 (w2 =...
Association of Synapsin III Gene with Adult Attention Deficit Hyperactivity Disorder
ERDAL, MEHMET EMİN
It was aimed to investigate the association of the synapsin III gene - 196 G> A and - 631 C>G polymorphisms that takes place in an encoding presynaptic protein, with adult attention deficit hyperactivity disorder (ADHD). One hundred thirty-nine patients having adult ADHD and 106 controls were included in the study. DNA samples were extracted from whole blood and genetic analyses were performed. A significant difference was determined between ADHD and synapsin III gene - 631 C>G polymorphism compared to the control group. No significant difference was determined between ADHD and synapsin III gene - 196 G>A polymorphism. These polymorphisms were found not to be associated with subtypes of ADHD. It is supposed that synaptic protein genes together with dopaminergic genes might have roles in th...