Monoamine oxidase-A gene promoter polymorphism in temporomandibular joint pain and dysfunction
Erdal, Mehmet Emin | Erdal, Nurten
Objective: In this study we aimed to evaluate the relationship between temporomandibular joint pain and dysfunction (TMJPD) within the frame of monoamine oxidase-A gene (MAO-LPR) gene polymorphism. Methods: Ninety-three patients with TMJPD, and 91 healthy volunteers were included in the study. Symptom Checklist-90-Revised (SCL-90-R), Montgomery-Asberg Depression Rating Scale (MADRS), and State and Trait Anxiety Inventory tests (STAI-I and STAI-II) were applied to the patients that were diagnosed as having TMJPD according to the standard clinical examination protocol. Blood samples were taken from the patients, and the variability in the MAO-A gene was analyzed by amplification of DNA with polymerase chain reaction (PCR) for a genetic association study. Results: The analysis of allele and g...
Monoamine oxidase-A gene promoter polymorphism in female migraineurs
Erdal, Mehmet Emin
Objective: To assess whether there is a relationship between monoamine oxidase-A (MAOA) gene promoter polymorphism and migraine in female patients. Study design: A polymerase chain reaction based study in which MAOA promoter polymorphism was studied in 54 female migraineurs and 52 controls. Methods: The low (3-repeat) and high (one of 3.5, 4 or 5 repeat units) activityMAOA alleles were detected. The genotypes and allele frequencies were compared both within and between the groups. Results: The representation of both low (1/ 1) and high (2/ 2) activity genotypes were similar between the female migraineurs and controls. The allele frequencies were also similar between these groups. There was no relationship between the presence or absence of aura and MAO polymorphism. Conclusion: MAOA gene p...
Significance of catechol-O-methyltransferase gene polymorphism in myofacial pain syndrome
Erdal, Mehmet Emin
The objective was to investigate possible association of the catechol o-methyl transferase (COMT) gene polymorphisms with myofacial pain syndrome (MFPS). The polymorphism of the COMT gene was compared between 49 patients with MFPS and 113 control subjects. Relationship between COMT polymorphism and psychiatric status of the patients was also assessed using SCL-90-R, BDS, and STAI-I and II tests. A PCR-based restriction fragment length polymorphismassay was used to detect G ! A transition at position 1947 in COMT. There was no relationship between MFPS and COMT polymorphism (p > 0:05). The patients who had MFPS without any temporomandibular joint problem had signi cantly higher expression of LL genotype when compared to those with joint problems (p < 0:05). There was no relationship betwee...
The 1438G/A polymorphism of the 5-HT2A receptor gene is associated with aura in migraine
Erdal, Mehmet Emin
Objective: To nd out the role of the 1438G/A polymorphismof the 5-HT2A promoter region in migraine. Study design: A polymerase chain reaction (PCR) analysis of the 1438G/A polymorphism was performed in 61 migraineurs and 57 healthy controls. Methods: The results of 1438G/A polymorphism were compared between the migraineurs and controls as well as between migraineurs with aura (MA) and those without aura (MOA). Results: The 1438 G/A polymorphism of 5-HT2A receptor gene was similar in both migraineurs and controls .p D 0:6/. There was a signi cant relationshipbetween the presence of G/G genotype and MA .p D 0:02/ while A/A and A/G genotypes were similar in both MA and MOA .p > 0:05/. Conclusion: The 1438G/A polymorphism of the 5-HT2A receptor gene is not associated with increased risk of ...