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The Pain Clinic4
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DNA AND CELL BIOLOGY3
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Psychiatry Investig3
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Neuropsychiatric Disease and Treatment2
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Rheumatology International2
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American Journal of Medical Genetics Part B: Neuropsychiatric Genetics (AJMGB)1
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American Journal of Orthodontics and Dentofacial Orthopedics1
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DEPRESSION AND ANXIETY1
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European Psychiatry1
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European Review for Medical and Pharmacological Sciences1
Tardive dyskinesia is not associated with the polymorphisms of 5-HT2A receptor gene, serotonin transporter gene and catechol-o-methyltransferase gene
Erdal, Mehmet Emin
Background. – The pathophysiology of tardive dyskinesia (TD) is not completely understood. Aim. – To assess the relationship of TD with 5-HT2A receptor gene, serotonin transporter gene (5 HTT), and catechol-o-methyltransferase (COMT) gene polymorphisms. Method. – Our study comprised 111 unrelated subjects who strictly met DSM-IV criteria for schizophrenia and 32 TD, and 79 healthy unrelated controls; all the subjects were of Turkish origin. The analyses of 5-HT2A receptor gene, 5 HTT gene, and COMT gene polymorphisms were performed using polymerase chain reaction (PCR) technique. Results. – The polymorphisms of these genes were not significantly different between the schizophrenic patients, TD and control subjects. Conclusion. – Our findings indicated that 5-HT2A receptor gene, 5 HTT gene,...
Significance of catechol-O-methyltransferase gene polymorphism in myofacial pain syndrome
Erdal, Mehmet Emin
The objective was to investigate possible association of the catechol o-methyl transferase (COMT) gene polymorphisms with myofacial pain syndrome (MFPS). The polymorphism of the COMT gene was compared between 49 patients with MFPS and 113 control subjects. Relationship between COMT polymorphism and psychiatric status of the patients was also assessed using SCL-90-R, BDS, and STAI-I and II tests. A PCR-based restriction fragment length polymorphismassay was used to detect G ! A transition at position 1947 in COMT. There was no relationship between MFPS and COMT polymorphism (p > 0:05). The patients who had MFPS without any temporomandibular joint problem had signi cantly higher expression of LL genotype when compared to those with joint problems (p < 0:05). There was no relationship betwee...
Significance of catechol-O-methyltransferase gene polymorphism in fibromyalgia syndrome.
Erdal, Mehmet Emin | Erdal, Nurten
Fibromyalgia syndrome (FS) is associated with a neuroendocrinal disorder characterized by abnormal function of the hypothalamic-pituitary-adrenal (HPA) axis, including hyperactive adrenocorticotropic hormone (ACTH) release and adrenal hyporesponsiveness. Catechol-O-methyltransferase (COMT) enzyme inactivates catecholamines and catecholamine-containing drugs. Polymorphism in the gene encodes for the COMT enzyme. For this study, the significance of COMT polymorphism was assessed in FS. There were three polymorphisms of the COMT gene: LL, LH, and HH. The analysis of COMT polymorphism was performed using polymerase chain reaction (PCR). Sixty-one patients with FS and 61 healthy volunteers were included in the study. Although no significant difference was found between LL and LH separately, the...
Association of serotonin transporter gene-linked polymorphic region and variable number of tandem repeat polymorphism of the serotonin transporter gene in lichen simplex chronicus patients with psychiatric status
Erdal, Mehmet Emin
Background The serotonin (5-hydroxytryptamine; 5-HT) is a key neurotransmitter in the central nervous system and a responsible mediator for the itch. Dysregulation of serotonergic pathways has been implicated in the pathogenesis of many complex neuropsychiatric diseases. Objectives The purpose of this study was to evaluate the relationship between lichen simplex chronicus and dysfunction and serotonin transporter (5-HTT) gene polymorphism. Methods Thirty-nine patients with lichen simplex chronicus and 61 healthy control subjects were examined. Results The results for the patients and control subjects were not significantly different ( P > 0.05) in long/long (L/L) and long/short (L/S) genotypes of 5-HTT gene-linked polymorphic region (HTTLPR) polymorphism, but short/short S/S genotype was l...
Monoamine oxidase-A gene promoter polymorphism in female migraineurs
Erdal, Mehmet Emin
Objective: To assess whether there is a relationship between monoamine oxidase-A (MAOA) gene promoter polymorphism and migraine in female patients. Study design: A polymerase chain reaction based study in which MAOA promoter polymorphism was studied in 54 female migraineurs and 52 controls. Methods: The low (3-repeat) and high (one of 3.5, 4 or 5 repeat units) activityMAOA alleles were detected. The genotypes and allele frequencies were compared both within and between the groups. Results: The representation of both low (1/ 1) and high (2/ 2) activity genotypes were similar between the female migraineurs and controls. The allele frequencies were also similar between these groups. There was no relationship between the presence or absence of aura and MAO polymorphism. Conclusion: MAOA gene p...
Significance of serotonin transporter gene polymorphism in migraine
Erdal, Mehmet Emin | Barlas, İbrahim Ömer
ObjectiÕe. To elucidate significance of the serotonin transporter gene ŽSTG. polymorphism in migraine, and to address the polymorphic patterns of STG, both in the migraineurs and healthy people in this country. Study design. A PCR study of STG in 52 migraineurs and 80 healthy controls. Methods. Using the PCR technique, STG polymorphism was studied in the DNA obtained from leukocytes of the patients and healthy controls. Polymorphism of the two regions ŽVNTR and 5-HTTLPR. of STG was assessed. Results. VNTR STin 2.10 and STin 2.12 alleles were detected in migraineurs and healthy controls. Both homozygous and heterozygous STin 2.10 allele predominated in the migraine group Ž ps0.01., while STin 2.12 allele was more frequent in the healthy controls Ž ps0.02.. There was no relationship between ...
T102C polymorphism of the 5-HT2A receptor gene may be associated with temporomandibular dysfunction
Erdal, Mehmet Emin
OBJECTIVE: To assess whether a relationship existed between the T102C polymorphism of 5-HT2A receptor gene and temporomandibular dysfunction. METHODS: Sixty-three patients with temporomandibular dysfunction, and 54 healthy volunteer controls were included in the study. Molecular analysis of the T102C polymorphism of the 5-HT2A receptor gene was performed using PCR technique. RESULTS: The C/C genotype was over represented in the patients whereas T/T genotype was over represented in the controls (P < 0.05). The genotype distribution of the patients who had temporomandibular dysfunction was not different than those who did not have temporomandibular dysfunction (P > 0.05). CONCLUSION: The T102C polymorphism may be involved in the etiology of temporomandibular dysfunction. The overrepresentati...
Association of VAMP-2 and Syntaxin 1A Genes with Adult Attention Deficit Hyperactivity Disorder
Ay, Özlem İzci | Erdal, Mehmet Emin
ObjectiveaaThe etiology of attention deficit hyperactivity disorder (ADHD) has not been entirely clarified yet. Structural and metabolic differences at the prefrontal striatal cerebellary system and the interaction of gene and environment are the main factors that thought to play roles in the etiology. Genetic investigations are performed especially about the dopamine pathways and receptors. In this study; it was aimed to investigate the association of the synaptobrevin-2 (VAMP-2) gene Ins/Del polymorphism and syntaxin 1A gene intron 7 polymorphism, which take place in encoding presynaptic protein, with adult ADHD. MethodsaaOne hundred thirty-nine patients, having ADHD aging between 18 and 60 years and 106 healthy people as controls were included into the study. DNA samples were extracted ...
Association Among SNAP-25 Gene DdeI and MnlI Polymorphisms and Hemodynamic Changes During Methylphenidate Use: A Functional Near-Infrared Spectroscopy Study
Erdal, Mehmet Emin | Ay, Mustafa Ertan
Objective—To investigate the interaction of treatment-related hemodynamic changes with genotype status for Synaptosomal associated protein 25 (SNAP-25) gene in participants with attention deficit hyperactivity disorder (ADHD) on and off single dose short-acting methylphenidate treatment with functional near-infrared spectroscopy (fNIRS). Method—A total of 15 right-handed adults and 16 right-handed children with DSM-IV diagnosis of ADHD were evaluated. Ten milligrams of short-acting methylphenidate was administered in a crossover design. Results—Participants with SNAP-25 DdeI T/T genotype had decreased right deoxyhemoglobin ([HHb]) with treatment. SNAP-25 MnlI genotype was also associated with right deoxyhemoglobin ([HbO2]) and [HHb] changes as well as left [HHb] change. When the combinatio...
Brain-Derived Neurotrophic Factor Gene Val66Met Polymorphism Is a Risk Factor for Attention-Deficit Hyperactivity Disorder in a Turkish Sample
ERDAL, MEHMET EMİN
ObjectiveaaAttention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that negatively affects different areas of life. We aimed to evaluate the associations between the Val66Met polymorphism of brain-derived neurotrophic factor (BDNF) and ADHD and to assess the effect of the BDNF polymorphism on the neurocognitive profile and clinical symptomatology in ADHD. MethodsaaTwo hundred one ADHD cases and 99 typically developing subjects (TD) between the ages of 8 and 15 years were involved in the study. All subjects were evaluated using a complete neuropsychological battery, Child Behavior Checklist, the Teacher’s Report Form (TRF) and the DSM-IV Disruptive Behavior Disorders Rating Scale-teacher and parent forms. ResultsaaThe GG genotype was significantly more frequent in t...
Monoamine oxidase-A gene promoter polymorphism in temporomandibular joint pain and dysfunction
Erdal, Mehmet Emin | Erdal, Nurten
Objective: In this study we aimed to evaluate the relationship between temporomandibular joint pain and dysfunction (TMJPD) within the frame of monoamine oxidase-A gene (MAO-LPR) gene polymorphism. Methods: Ninety-three patients with TMJPD, and 91 healthy volunteers were included in the study. Symptom Checklist-90-Revised (SCL-90-R), Montgomery-Asberg Depression Rating Scale (MADRS), and State and Trait Anxiety Inventory tests (STAI-I and STAI-II) were applied to the patients that were diagnosed as having TMJPD according to the standard clinical examination protocol. Blood samples were taken from the patients, and the variability in the MAO-A gene was analyzed by amplification of DNA with polymerase chain reaction (PCR) for a genetic association study. Results: The analysis of allele and g...
Relationship between the DAT1 gene and the effects of methylphenidate administration in adult attention deficit hyperactivity disorder: a magnetic resonance spectroscopy study
Erdal, Mehmet Emin
Abstract. – OBJECTIVE: This study investigated the relationship between DAT1 gene polymorphisms and the effects of methylphenidate (MPH) administration on N-acetyl aspartate (NAA), creatine (Cr), and choline (Cho) levels in the anterior cingulate cortex, prefrontal cortex, striatum, and cerebellum in adult patients with attention deficit hyperactivity disorder (ADHD). This was the first study to investigate the relationship between DAT gene variable number tandem repeat (VNTR) polymorphisms and the responses of brain metabolites to MPH. PATIENTS AND METHODS: Samples in this study were collected from 60 patients aged between 18 and 60 years with ADHD according to DSM-IV criteria. Genetic analysis of DAT1 gene polymorphisms was carried out using blood samples obtained after a detailed clinic...
Catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association between symptomatology and prognosis
Erdal, Mehmet Emin
Catechol-O-methyltransferase (COMT) gene has long been implicated to play a role in the pathogenesis of schizophrenia. The aim of this study is to assess the relationship of schizophrenia and its subgroups with COMT gene polymorphism. We have attempted to evaluate a possible correlation between the severity and prognosis of the illness (the psy- chopathology of symptoms) and COMT gene polymorphisms. The study comprised 129 unrelated subjects who strictly met DSM-IV criteria for schizophrenia, and 65 healthy unrelated controls. All subjects were of Turkish origin. A clinical evaluation of all patients was accomplished by applying the Brief Psychiatric Rating Scale (BPRS) test. The analysis of COMT polymorphism was performed using the polymerase chain reaction technique. Regarding COMT gene ...
LACK OF ASSOCIATION OF CATECHOL-OMETHYLTRANSFERASE GENE POLYMORPHISM IN OBSESSIVE–COMPULSIVE DISORDER
Erdal, Mehmet Emin | Acar, Şenel | Yazıcı, Mustafa Kemal | Yazıcı, Aylin Ertekin | Eker, Ebru Derici
The COMT gene has been implicated to be involved in the pathogenesis of obsessive–compulsive disorder (OCD) and various other psychiatric disorders. COMTenzyme activity is governed by a common genetic polymorphism at codon 158 that results in substantial 3- to 4-fold variation in enzymatic activity [a high-activity COMT variant (H) and a low activity variant (L)]. This study evaluates the association between OCD and the COMT gene polymorphism. Fifty-nine OCD patients that were diagnosed according to DSM-IV criteria and 114 healthy control subjects were included in the study. PCR technique was used for molecular analysis. The genotypic pattern of distribution of the COMT gene (H/H, H/L, and L/L genotypes) was not different between the OCD patients and controls. There were no significant dif...
Is the dopamine D3 receptor mRNA on blood lymphocytes help to for identification and subtyping of schizophrenia?
Erdal, Mehmet Emin
Abstract Schizophrenia is one of the neuropathological disorders, which are associated with dopamine and its receptors. In recent years, it has been shown that mRNA of D3, D4 and D5 dopamine receptor (DRD3, DRD4, DRD5) subtypes is expressed in human peripheral blood lymphocytes (PBL). A total 55 schizophrenic patients and 51 healthy subjects were included in the study to investigate the levels of DRD3 mRNA in PBL of schizophrenic patients and whether DRD3 mRNA level in PBL can serve as peripheral marker for schizophrenia. RNA was isolated from lymphocytes of both groups and reverse transcriptase polymerase chain reaction (RT-PCR) was performed for DRD3 mRNA. We found a significant difference in PBL DRD3 mRNA levels among schizophrenia subtypes (P = 0.030) while no difference was detected b...
The Association of Olanzapine-Induced Weight Gain with Peroxisome Proliferator–Activated Receptor-g2 Pro12Ala Polymorphism in Patients with Schizophrenia
Erdal, Mehmet Emin | Barlas, İbrahim Ömer
Olanzapine is a second-generation antipsychotic that may cause weight gain and metabolic syndrome in some cases. The peroxisome proliferator–activated receptor (PPAR)-g is an important gene in the progress of type II diabetes and metabolic syndrome. In recent studies the polymorphism of the PPAR-g has been studied in type II diabetes mellitus, polycystic ovary syndrome, and insulin resistance syndrome. It is aimed to evaluate the association between polymorphism of PPAR-g gene and olanzapine-induced weight gain. Our study comprised 95 unrelated subjects who strictly met Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSMIV) criteria for schizophrenia, and all were of Turkish origin. All patients were evaluated with rating scales, and genetic analyses were performed. We ...