Monoamine oxidase-A gene promoter polymorphism in female migraineurs
Erdal, Mehmet Emin
Objective: To assess whether there is a relationship between monoamine oxidase-A (MAOA) gene promoter polymorphism and migraine in female patients. Study design: A polymerase chain reaction based study in which MAOA promoter polymorphism was studied in 54 female migraineurs and 52 controls. Methods: The low (3-repeat) and high (one of 3.5, 4 or 5 repeat units) activityMAOA alleles were detected. The genotypes and allele frequencies were compared both within and between the groups. Results: The representation of both low (1/ 1) and high (2/ 2) activity genotypes were similar between the female migraineurs and controls. The allele frequencies were also similar between these groups. There was no relationship between the presence or absence of aura and MAO polymorphism. Conclusion: MAOA gene p...
Significance of serotonin transporter gene polymorphism in migraine
Erdal, Mehmet Emin | Barlas, İbrahim Ömer
ObjectiÕe. To elucidate significance of the serotonin transporter gene ŽSTG. polymorphism in migraine, and to address the polymorphic patterns of STG, both in the migraineurs and healthy people in this country. Study design. A PCR study of STG in 52 migraineurs and 80 healthy controls. Methods. Using the PCR technique, STG polymorphism was studied in the DNA obtained from leukocytes of the patients and healthy controls. Polymorphism of the two regions ŽVNTR and 5-HTTLPR. of STG was assessed. Results. VNTR STin 2.10 and STin 2.12 alleles were detected in migraineurs and healthy controls. Both homozygous and heterozygous STin 2.10 allele predominated in the migraine group Ž ps0.01., while STin 2.12 allele was more frequent in the healthy controls Ž ps0.02.. There was no relationship between ...
Significance of the catechol-O-methyltransferase gene polymorphism in migraine
Erdal, Mehmet Emin
The objective was to assess the significance of the catechol-o-methyltransferase (COMT) enzyme polymorphism in migraine. For this reason, 62 migraineurs and 64 healthy volunteers were included in the study. The analysis of COMT polymorphism was performed using PCR. The H/H genotype was more frequent in the control group than in the patients group (P50.032). The homozygous or heterozygous L allele was over represented in the migraineurs compared with the controls (P50.013). The L/L genotype was over represented in the migraineurs who also had a family history of migraine (P50.003). There was no relationship between aura and COMT genotypes. In conclusion, the COMT polymorphism may be of potential pharmacological importance regarding the individual differences in the metabolism of catechol dr...
The 1438G/A polymorphism of the 5-HT2A receptor gene is associated with aura in migraine
Erdal, Mehmet Emin
Objective: To nd out the role of the 1438G/A polymorphismof the 5-HT2A promoter region in migraine. Study design: A polymerase chain reaction (PCR) analysis of the 1438G/A polymorphism was performed in 61 migraineurs and 57 healthy controls. Methods: The results of 1438G/A polymorphism were compared between the migraineurs and controls as well as between migraineurs with aura (MA) and those without aura (MOA). Results: The 1438 G/A polymorphism of 5-HT2A receptor gene was similar in both migraineurs and controls .p D 0:6/. There was a signi cant relationshipbetween the presence of G/G genotype and MA .p D 0:02/ while A/A and A/G genotypes were similar in both MA and MOA .p > 0:05/. Conclusion: The 1438G/A polymorphism of the 5-HT2A receptor gene is not associated with increased risk of ...
The A218C polymorphism of tryptophan hydroxylase gene and migraine
Erdal, Nurten | Erdal, Mehmet Emin
Objective: To determine the significance of the A218C polymorphism of the tryptophan hydroxylase (TPH) gene in migraine. Methods: Fifty-nine migraineurs and 62 healthy controls were included in the study, and polymerase chain reaction – restriction fragment length polymorphism assays were used to determine TPH A218C polymorphism. Results: There was no association between TPH gene polymorphism and gender, family history of migraine and epilepsy, or aura. There was no significant difference between the allele frequencies of both groups (p > 0.05). A significant difference was found between the genotypes of the migraineurs and controls regarding the AA genotype. Homozygosity for the C allele or heterozygosity for the A or C was not associated with the occurrence of migraine (p > 0.05), but ho...