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Fakülteler107
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Tıp Fakültesi107
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Temel Tıp Bilimleri Bölümü107
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Tıbbi Biyoloji ve Genetik Anabilim Dalı67
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Tıbbi Mikrobiyoloji Anabilim Dalı20
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Biyofizik Anabilim Dalı10
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Cerrahi Tıp Bilimleri Bölümü9
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Kadın Hastalıkları ve Doğum Anabilim Dalı9
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Biyoistatistik ve Tıbbi Bilişim Anabilim Dalı8
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Histoloji ve Embriyoloji Anabilim Dalı8
Description of the episeptal and interlaminar fascial tunnels for the superficial fibular nerve and its terminal branches.
KESİLMİŞ İNCİ | KURTOĞLU OLGUNUS ZELİHA
Purpose This study aimed to reveal the course of the superficial fibular nerve and its branches, whose entrapment may be responsible for anterior leg pain and is at risk in fasciotomies, according to the crural fascia laminae and the anterior inter muscular septum. Methods On the twenty cadaver legs, the location of the superficial fibular nerve and its branches, according to the crural fascia layers and anterior intermuscular septum, the course type in the tunnel, if any, and the superficialization pattern were defined. Results The number of cases in which the superficial fibular nerve and its branches traveled within a tunnel was found to be 15/20 (75%). The superficial fibular tunnel was defined as an “episeptal” and “interlaminar fascial” tunnel based on the nerve’s relati...
Tardive dyskinesia is not associated with the polymorphisms of 5-HT2A receptor gene, serotonin transporter gene and catechol-o-methyltransferase gene
Erdal, Mehmet Emin
Background. – The pathophysiology of tardive dyskinesia (TD) is not completely understood. Aim. – To assess the relationship of TD with 5-HT2A receptor gene, serotonin transporter gene (5 HTT), and catechol-o-methyltransferase (COMT) gene polymorphisms. Method. – Our study comprised 111 unrelated subjects who strictly met DSM-IV criteria for schizophrenia and 32 TD, and 79 healthy unrelated controls; all the subjects were of Turkish origin. The analyses of 5-HT2A receptor gene, 5 HTT gene, and COMT gene polymorphisms were performed using polymerase chain reaction (PCR) technique. Results. – The polymorphisms of these genes were not significantly different between the schizophrenic patients, TD and control subjects. Conclusion. – Our findings indicated that 5-HT2A receptor gene, 5 HTT gene,...
The Tumor Necrosis Factor-A -308 G/A Polymorphism and the Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Polymorphisms, in Asthmatic Patients and Healthy Subjects
Erdal, Mehmet Emin | Ay, Özlem İzci
Asthma is a chronic inflammatory disorder of the airways in which many cells and cellular elements play a role. Like other atopic diseases, asthma is a complex disorder caused by interactions between multiple genes of small to modest effect and equally important environmental factors. The aim of this study was to determine the TNF-α -308 G/A polymorphism and the TRAIL polymorphisms, and their influence on asthma in asthmatic patients and healthy subjects. The study population consists of 51 asthmatic patients (47 female and 4 male) and 72 healthy subjects (62 female and 10 male). The mean age of the asthmatic patients and healthy controls were 45.33±14.05, and 41.88±17.41 years, respectively. The asthmatic patients and healthy controls were similar with respect to their ages and sex charac...
Examination of individuals' depression, anxiety, and stress levels during the COVID-19 pandemic in Turkey
Erdoğan, Semra | Can, Ahu Aksoy | Yılmaz, Duygu Vefikuluçay
Purpose: This research was conducted to determine the depression, anxiety, and stress levels of individuals during the COVID-19 epidemic. In addition, the compatibility of the Depression-Anxiety-Stress Scale (DASS-21) scale results with the participants' feeling depressed, anxious, and stressed were examined. Design and methods: The sample of the study consisted of 870 individuals over the age of 18 between May–August 2021. The data of the study were collected online, using the personal information form and DASS-21. Results: In our study, it was observed that 22.3 % of the participants were severely depressed, 19.0 % were highly anxious and 14.3 % were highly stressed. In addition, a relationship was determined between many sociodemographic variables and depression, anxiety, and stress lev...
Deep Learning-Based Prediction Models for the Detection of Vitamin D Deficiency and 25-Hydroxyvitamin D Levels Using Complete Blood Count Tests
Acı, Çiğdem | Acı, Mehmet
Vitamin D (VitD) is an essential nutrient that is critical for the well-being of both adults and children, and its deficiency is recognized as a precursor to several diseases. In previous studies, researchers have approached the problem of detecting vitamin D deficiency (VDD) as a single ”sufficient/deficient” classification problem using machine learning or statistics-based methods. The main objective of this paper is to predict a patient’s VitD status (i.e., sufficiency, insufficiency, or deficiency), severity of VDD (i.e., mild, moderate, or severe), and 25-hydroxyvitamin D (25(OH)D) level in a separate deep learning (DL)-based models. An original dataset consisting of complete blood count (CBC) tests from 907 patients, including 25(OH)D concentrations, collected from a public health la...
Investigation of the anticancer of photodynamic therapy effects by using the novel Schiff base ligand palladium complexes on human breast cancer cell line
Demirbağ, Burcu | Ballı, Ebru | Orekici Temel, Gülhan | Yılmaz, Mustafa Kemal | Değirmenci, Evren | Kibar, Deniz
Chemotherapy plays a role in many cancer therapies, including breast cancer, but due to its significant side effects, alternate treatment approaches have been investigated. One such alternative is photodynamic therapy (PDT), which employs a combination of oxygen, a photosensitizer (PS), and light of a specific wavelength. Transition metal complexes and SBL have gained interest in PDT. In this study aimed to assess the potential antitumor activity and underlying mechanism of a newly synthesized Schiff base ligand (SBL)-mediated PDT on MCF-7 cells, comparing its efficacy to cisplatin. We synthesized and characterized two novel Pd-conjugated SBL compounds (complex-1 and 2). Following the treatment of MCF-7 cells with these compounds, a light-emitting diode (LED) was utilized to deliver a ligh...
Association of insulin receptor substrate-1 G972R variant with baseline characteristics of the patients with gestational diabetes mellitus
Tok, Devrim | Erdal, Mehmet Emin
Objective: Insulin receptor substrate-1 (IRS-1) expression and tyrosine phosphorylation is decreased during pregnancy. Pregnancy may be a suitable condition to detect any abnormalities related to IRS-1 polymorphisms. Therefore, we aimed to investigate the prevalence and metabolic impacts of IRS-1 G972R polymorphism in patients with gestational diabetes mellitus (GDM). Study design: Anthropometric and metabolic variables of 62 women who were diagnosed as having GDM according to 100 g oral glucose tolerance test were compared on the basis of IRS-1 polymorphism by univariate analysis of covariance. Results: Patients with IRS-1 G972R were more obese at the beginning of pregnancy, had higher serum fasting insulin and glucose levels. Weight gain during pregnancy and insulin and glucose levels af...
Association of NRG3 and ERBB4 gene polymorphism with nicotine dependence in Turkish population
Erdal, Mehmet Emin
Background Nicotine dependence (ND) is characterized by regular smoking, anxiety, irritation, difficulty concentrating, impatience, restlessness, tremor, dizziness, hunger, nicotine demand, and the individual’s reluctance to quit despite knowing the health risks of smoking. Recently, it has been reported that the Neuregulin 3 (NRG3)/Erb-B2 receptor tyrosine kinase 4 (ERBB4) signaling pathway plays a role in ND. NRG3, which is activated after nicotine intake, binds to ERBB4 and causes GABA release. GABA reduces anxiety and tension, which are one of the nicotine withdrawal symptoms. Therefore we aimed to investigate the relationship between NRG3 and ERBB4 gene polymorphisms and ND. Materials and methods The study population was comprised of patients with ND (n = 200) and healthy non-smoker c...
The ameliorating effect of silymarin against vancomycin-induced apoptosis and inflammation in rat liver
Güzel Kara, Sevda | Uçkun Şahinoğulları, Zuhal | Canacankatan, Necmiye | Antmen, Ş. Efsun | Kibar, Deniz
Silymarin (SL), a flavonolignan complex isolated from seeds of Silybum marianum (Asteraceae), is known for its hepatoprotective, anti-apoptotic, anti-inflammatory, and antioxidant activities. A glycopeptide antibiotic, Vancomycin (VA) which is used for the treatment of serious infections caused by multi-resistant Gram-positive microorganisms has been clinically used for a long time. The aim of the present study was to evaluate potential therapeutic efficiency of SL against VA-induced apoptosis and inflammation using apoptotic (caspase-3, -8, and, -9) enzyme activities) and inflammatory (Tumor necrosis factor-alpha (TNF-α)) markers, and histopathological examinations in rat liver. A total of 49 male Wistar albino rats was divided into 7 groups including control (saline, intraperitoneally (i...
Association between Cathechol-O-Metyltransferase polymorphism and psoriasis
Erdal, Mehmet Emin | Türsen, Ümit | Kaya, Tamer İrfan | Kanık, Emine Arzu | Eker, Ebru Derici | İkizoğlu, Güliz
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Serotonin transporter gene polymorphisms in patients with chronic tension-type headache: A preliminary study
Erdal, Mehmet Emin
Background and Objectives: This study is designed to understand the pathophysiology of one of the most serious health problems, chronic tension-type headache (CTTH). Two polymorphic sites in serotonin transporter protein gene attracted much interest. These are: the variable number of tandem repeats (VNTR) and 5'-flanking promoter region (5-HTTLPR). Materials and Methods: VNTR and 5-HTTLPR polymorphisms were investigated in 126 CTTH patients and 138 healthy control subjects. The patients were being treated with amitripytyline or citalopram or sertraline (SSRI). The polymerase chain reaction (PCR) method was used to investigate the polymorphisms in the serotonin transporter protein gene. Results: There were no statistically significant results based on the 5-HTTLPR gene alleles, however, STi...
Association of GABA B R1 Receptor Gene Polymorphism with Obstructive Sleep Apnea Syndrome
Erdal, Mehmet Emin
Objective: GABABR (gamma-amino butyric acid B receptor)-mediated neurotransmission has been implicated in the pathophysiology of a variety of neuropsychiatric disorders. GABABR1 gene variants were identified by single-strand conformation analysis. The nucleotide exchanges cause a substitution of alanine to valine in exon 1a1 (Ala20Val), a substitution of glycine to serine in exon 7 (Gly489Ser) and a silent C to G nucleotide exchange encoding the amino acid phenylalanine in exon 11 (Phe658Phe). The significance of GABABR1a gene polymorphism in obstructive sleep apnea syndrome (OSAS) as well as the association of these polymorphisms with the polysomnography findings in OSAS patients are not known. In this study, we aimed to assess the significance of 3 different GABABR1 gene polymorphisms (A...
Significance of serotonin transporter gene polymorphism in migraine
Erdal, Mehmet Emin | Barlas, İbrahim Ömer
ObjectiÕe. To elucidate significance of the serotonin transporter gene ŽSTG. polymorphism in migraine, and to address the polymorphic patterns of STG, both in the migraineurs and healthy people in this country. Study design. A PCR study of STG in 52 migraineurs and 80 healthy controls. Methods. Using the PCR technique, STG polymorphism was studied in the DNA obtained from leukocytes of the patients and healthy controls. Polymorphism of the two regions ŽVNTR and 5-HTTLPR. of STG was assessed. Results. VNTR STin 2.10 and STin 2.12 alleles were detected in migraineurs and healthy controls. Both homozygous and heterozygous STin 2.10 allele predominated in the migraine group Ž ps0.01., while STin 2.12 allele was more frequent in the healthy controls Ž ps0.02.. There was no relationship between ...
Lack of Effect of Extremely Low Frequency Electromagnetic Fields on Cyclin-Dependent Kinase 4 Inhibitor Gene p18INK4C in Electric Energy Workers.
Erdal, Nurten | Erdal, Mehmet Emin
Background. Long-term exposure to extremely low frequency magnetic fields (ELF-MFs) may be a risk factor for human cancer. One mechanism through which ELF-MFs could influence neoplastic development is the deletion/mutation of cancer-related genes. Cellular proliferation follows an orderly progression through the cell cycle, which is governed by different cyclins and cyclin-dependent kinase inhibitors (CDKIs). The putative tumor suppressor gene p18INK4C encodes a specific inhibitor of cyclin D-cyclin-dependent kinase 4 inhibitor complexes having an important role in cell-cyclin regulation. It has been found to be deleted/mutated in a variety of human cancers. Therefore, this study is to investigate whether or not long-term extremely low frequency electromagnetic field exposure may be a risk...
T102C polymorphism of the 5-HT2A receptor gene may be associated with temporomandibular dysfunction
Erdal, Mehmet Emin
OBJECTIVE: To assess whether a relationship existed between the T102C polymorphism of 5-HT2A receptor gene and temporomandibular dysfunction. METHODS: Sixty-three patients with temporomandibular dysfunction, and 54 healthy volunteer controls were included in the study. Molecular analysis of the T102C polymorphism of the 5-HT2A receptor gene was performed using PCR technique. RESULTS: The C/C genotype was over represented in the patients whereas T/T genotype was over represented in the controls (P < 0.05). The genotype distribution of the patients who had temporomandibular dysfunction was not different than those who did not have temporomandibular dysfunction (P > 0.05). CONCLUSION: The T102C polymorphism may be involved in the etiology of temporomandibular dysfunction. The overrepresentati...