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170648

Pharmacological Inhibition of Mammalian Target of Rapamycin Attenuates Deoxycorticosterone Acetate Salt–Induced Hypertension and Related Pathophysiology: Regulation of Oxidative Stress, Inflammation, and Cardiovascular Hypertrophy in Male Rats

Temiz Reşitoğlu, Meryem | Sucu, Nehir | Kibar, Deniz | Yılmaz, Şakir Necat | Tunçtan, Bahar | Şahan Fırat, Seyhan

The present study aimed to explore the contribution of mammalian target of rapamycin (mTOR) in deoxycorticosterone acetate (DOCA) salt–induced hypertension and related pathophysiological changes in cardiovascular and renal tissues. DOCA salt loading resulted in an increase in systolic blood pressure, diastolic blood pressure, and mean blood pressure along with the activity of ribosomal protein S6, the effector protein of mTOR. Treatment with rapamycin, the selective inhibitor of mTOR, initiated at the fourth week of DOCA- salt administration normalized the systolic blood pressure and attenuated ribosomal protein S6 activity in the heart, aorta, and kidney. Cardiac and vascular hypertrophy, oxidative stress, and infiltration of macrophages (CD68+), the marker of inflammation, were also redu...

170615

mTOR inhibition as a possible pharmacological target in the management of systemic inflammatory response and associated neuroinflammation by lipopolysaccharide challenge in rats

Temiz Reşitoğlu, Meryem | Kibar, Deniz | Yılmaz, Şakir Necat | Tunçtan, Bahar | Şahan Fırat, Seyhan

Neuroinflammation plays a critical role during sepsis triggered by microglial activation. Mammalian target of rapamycin (mTOR) has gained attraction in neuroinflammation, however, the mechanism remains unclear. Our goal was to assess the effects of mTOR inhibition by rapamycin on inflammation, microglial activation, oxidative stress, and apoptosis associated with the changes in the inhibitor-κB (IκB)-α/nuclear factor-κB (NF-κB)/hypoxia-inducible factor-1α (HIF-1α) pathway activity following a systemic challenge with lipopolysaccharide (LPS). Rats received saline (10 mL/kg), LPS (10 mg/kg), and (or) rapamycin (1 mg/kg) intraperitoneally. Inhibition of mTOR by rapamycin blocked phosphorylated form of ribosomal protein S6, NF-κB p65 activity by increasing degradation of IκB-α in parallel with...

170617

Potential protective effects of naringenin against vancomycin-induced nephrotoxicity via reduction on apoptotic and oxidative stress markers in rats

Uçkun, Zuhal | Güzel, Sevda | Canacankatan, Necmiye | Kibar, Deniz | Coşkun Yılmaz, Banu

Vancomycin (VCM), a glycopeptide antibiotic, is a drug widely used in severe infections. However, VCM induce notable nephrotoxic side effects. Naringenin (NAR) is a natural of flavonoid and are known as strongly antioxidant, nefroprotective, antiapoptotic, and anti-inflammatory. The purpose of this study was to determine the potential protective effects of NAR against VCM-induced nephrotoxicity by measuring apoptotic and oxidative stress markers and evaluating histopathological alterations in rats. For this purpose, we used male Wistar albino rats that divided into seven groups: (i) Control [saline, intraperitoneally (i.p.)], (ii) carboxymethyl cellulose (0.5% CMC, orally), (iii) VCM (400 mg/kg, i.p.), (iv) NAR100 (100 mg/kg, orally), (v) VCM + NAR25 (25 mg/kg, orally), (vi) VCM + NAR50 (5...

166235

EKOLOJİK SU ÜRÜNLERİ ÜRETİMİ

Bilgüven, Murat

Yirminci yüzyılın ikinci yarısında yaşanan hızlı sanayileşme ve nüfus artışı, çevre sorunları yanında, artan nüfusun yeterince beslenememesi yani açlık sorunun ortaya çıkmasına neden olmuştur. Artan nüfusun beslenme gereksinimi, insanoğlunu tarımda birim alandan; maksimum ürün almaya yöneltmiştir. Birim alandan yüksek verim almaya yönelik yoğun ve bilinçsiz tarım ilacı ve gübre kullanılması ve sonuç olarak, bu kimyasalların tarımsal ürünlerde oluşturduğu ve yeraltı sularına karışarak içme sularında yarattığı kalıntılar, insan sağlığını ve yaşamını tehdit etmeye başlamıştır. Verim artışı ile yetinilmemiş, genetik bilimin tüm teknolojileri de kullanılmaya başlanmış, bitki ve hayvanların DNA yapıları değiştirilmiş, melezleme ve klonlama yöntemleri uygulanmıştır. Tüm bunların sonucunda ekoloji...

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