Evaluation of Biochemical Parameters in Coronary Artery Patients with Covid-19 Infection

Yaroğlu, Hatice Yıldırım | Yeşil, Emrah

As a result of pneumonia brought on by coronavirus disease (COVID-19), acute myocardial infarction, and chronic cardiovascular system damage, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells via ACE2 receptors. In patients with coronary artery disease (CAD) who are positive for COVID-19, early measurement of cardiac damage through biomarkers and careful monitoring of myocardial damage that may be caused by infection should be performed. The goal of this study was to retrospectively assess the results of biochemical laboratory testing in patients with CAD and COVID-19. Biochemical laboratory results of 70 patients with CAD and COVID-19 and 70 patients only with CAD were examined retrospectively. A signifcant difference was detected between groups in terms ...

Association with serum adropin levels and isolated coronary artery ectasia in patients with stable angina pectoris

Özkan, Buğra | Örsçelik, Özcan | Yaroğlu, Hatice Yıldırım | Balcı, Şenay | Özcan, Mert Koray | Çelik, Ahmet | Özcan, İsmail Türkay

Objective: Dilation of one or more coronary artery segments to a diameter at least 1.5 times that of a normal adjacent segment is referred to as coronary artery ectasia (CAE). Adropin is a protein involved in endothelial function and is shown to have a protective effect on the regulation of cardiac functions. Atherosclerosis and endothelial dysfunction play an important role in the development of CAE. The aim of this study was to investigate the association between serum adropin levels and isolated CAE. Methods: Patients with stable angina pectoris who underwent coronary angiography (CAG) between August 2017 and July 2018 were evaluated prospectively. A total of 92 subjects were included in the study-40 patients over 18 years old and diagnosed with isolated CAE based on CAG findings and a ...

Konjenital anomali prenatal taramalarında bir belirteç olarak mirna profilinin belirlenmesi

Balcı Fidancı, Şenay.

ÖZET KONJENİTAL ANOMALİ PRENATAL TARAMALARINDA BİR BELİRTEÇ OLARAK MİRNA PROFİLİNİN BELİRLENMESİ Genetik defekt, kromozomal anöploidi ve yapısal doğum kusurlarını tanımlamak için tarama testleri önerilmektedir. Birinci ve/veya ikinci trimesterde anöploidi risk değerlendirmesi yapmak için sonografik ve maternal serum bazlı seçenekler mevcuttur. Ayrıca prenatal tanı için koryon villus biyopsisi, amniyosentez gibi invasiv tanı yöntemleri kullanılmaktadır ve bu yöntemler fetus için somut bir risk taşıdığından, özellikle genetik hastalıkların doğru, kolay kullanılabilir ve noninvaziv prenatal tanı testi gerekliliği artmaktadır. Bununla birlikte, son yıllarda, fetal kromozomal anöploidilerin noninvaziv prenatal tanısında, dolaşımdaki fetal nükleik asitler ümit vaat eden moleküller haline gelmişt...

The effects of interleukin (IL)1, 6, 10 and tumor necrosis factor (TNF) gene polymorphisms on CRP levels in coronary artery disease

Ünal, Zeynep Nil | Yaroğlu, Hatice Yıldırım | Yılmaz, Dilek Çiçek | Tamer, Lülüfer

Atherosclerosis is a dynamic and progressing inflammatory pathology. Studies have demonstrated that genetic variants that directly or indirectly alter the inflammatory system raise the risk of coronary artery disease (CAD). Genetic variations account for the variances in how the disease develops and progresses as well as the disclosure of poor prognostic information linked to extreme inflammatory reactions in individuals. In our investigation, we aimed to determine whether there may be a connection between CAD and the IL-1 C-889T, IL-6 G-174C, IL-10 G-1082A, and TNF G-308A polymorphisms. In the study, 80 patients with coronary artery stenosis of 70% or more and 80 people with normal coronary arteries were both evaluated using coronary angiography. An enzymatic colorimetric approach was use...

The role of CYP2C9 gene polymorphism in rheumatoid arthritis

Yaroğlu, Hatice Yıldırım | Biçer, Ali

Background/Aim: The inflammatory disorder rheumatoid arthritis (RA) affects quality of life and worsens with symptoms in the extra-articular tissues and systemic joints. The most significant member of the Cytochrome P450 enzyme family, Cytochrome P450 2C9 (CYP2C9), plays an essential role in the alkylation, demethylation, and hydroxylation of a variety of substances. Insufficient studies as to whether the susceptibility to rheumatoid arthritis is genetic exists. Therefore, our study presents new information on whether CYPC9 is a genetic risk factor. In this study, we sought to determine whether rheumatoid arthritis and the CYP2C9 gene polymorphism are related. Methods: This study was conducted as a prospective case-control study. Fifty patients with RA and 50 healthy individuals were inclu...

The relationship between ghrelin and ghrelin leu72met polymorphism in coronary artery disease

Purpose: Ghrelin represents a hormone, which is defined as an endogenous ligand bound to the growth hormone-releasing hormone receptor (GHS-R1a). However, the mechanisms that underlie ghrelin’s impacts on cardiovascular diseases have not been completely detected. For this reason, we aimed to research the relationship between serum ghrelin and ghrelin gene polymorphism in coronary artery disease (CAD). Materials and Methods: The study group consisted of 88 patients diagnosed with a minimum of one coronary artery stenosis over 70%, and the control group comprised 81 individuals without coronary artery lesions. An autoanalyzer was used to analyze fasting blood glucose (FBG) and lipid parameter levels. Ghrelin levels were examined with an enzyme-linked immunosorbent assay (ELISA) kit. Results:...

The investigation of lipoprotein-related phospholipase A2 (LP-PLA2) V279F mutation in coronary artery disease

Yaroğlu, Hatice Yıldırım | Yılmaz, Dilek Çiçek | Tamer, Lülüfer

Objective: Despite advances in the treatment of cardiovascular diseases, coronary artery disease (CAD) maintains to be the leading cause of death in many nations. The media layer of normal and diseased arteries contains lipoprotein-associated phospholipase A2 (Lp-PLA2), which is mostly made by mast, T lymphocytes, and monocytes. Our research sought to define how the Lp-PLA2 and V279F gene polymorphisms relate to CAD. Materials and Methods: This study included 71 controls and 109 patients. Fasting blood glucose (FBG) and lipid profiles, were measured the enzymatic colorimetric technique. Lp-PLA2 levels were detected with ELISA. The genomic DNAs were isolated from whole blood. Real-time polymerase chain reaction (RT-PCR) with the V279F mutation detection kit was used to identify the Lp-PLA2 ...

EKOLOJİK SU ÜRÜNLERİ ÜRETİMİ

Bilgüven, Murat

Yirminci yüzyılın ikinci yarısında yaşanan hızlı sanayileşme ve nüfus artışı, çevre sorunları yanında, artan nüfusun yeterince beslenememesi yani açlık sorunun ortaya çıkmasına neden olmuştur. Artan nüfusun beslenme gereksinimi, insanoğlunu tarımda birim alandan; maksimum ürün almaya yöneltmiştir. Birim alandan yüksek verim almaya yönelik yoğun ve bilinçsiz tarım ilacı ve gübre kullanılması ve sonuç olarak, bu kimyasalların tarımsal ürünlerde oluşturduğu ve yeraltı sularına karışarak içme sularında yarattığı kalıntılar, insan sağlığını ve yaşamını tehdit etmeye başlamıştır. Verim artışı ile yetinilmemiş, genetik bilimin tüm teknolojileri de kullanılmaya başlanmış, bitki ve hayvanların DNA yapıları değiştirilmiş, melezleme ve klonlama yöntemleri uygulanmıştır. Tüm bunların sonucunda ekoloji...