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Fakülteler2
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Su Ürünleri Fakültesi2
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Su Ürünleri Avlama ve İşleme Teknolojisi Bölümü2
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Su Ürünleri Mühendisliği Bölümü2
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Su Ürünleri Temel Bilimleri Bölümü2
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Su Ürünleri Yetiştiriciliği Bölümü2
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Avlama Teknolojisi Anabilim Dalı2
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İşleme Teknolojisi Anabilim Dalı2
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Su Ürünleri Mühendisliği Anabilim Dalı2
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Balıkçılık Temel Bilimleri Anabilim Dalı2
Changes in Liver Tissue Trace Element Concentrations During Hepatitis B Viral Infection Treatment
Karayakar, Fahri | Çolak, Tahsin
Approximately 350–400 million people in the world have Hbs Ag (hepatitis B virus surface antigen) positivity. In the international guidelines, the permanent suppression of replication in chronic hepatitis B virus (HBV) infection therapy is reported as the primary therapeutic goal. Trace elements play a key role in liver diseases. The aim of our study is to determine some trace element concentrations in the liver during HBV treatment periods. The measurement of 11 trace elements (manganese, lead, nickel, chromium, cadmium, iron, copper, zinc, silver, cobalt, and aluminum) was carried out by the method of inductively coupled plasma mass spectrometry in liver biopsy materials (before starting treatment and at the sixth month of the treatment period). There was an increase in zinc and copper c...
Liver tissue trace element levels in HepB patients and the relationship of these elements with histological injury in the liver and with clinical parameters
Karayakar, Fahri | Çolak, Tahsin
Aim: In this study, the relationship of liver tissue trace element concentrations with hepatitis B disease and the effects of several environmental factors were analysed. Method: The liver tissue concentrations of Al, Fe, Cd, Mn, Cr, Cu, Pb, Ni, Zn, Ag, and Co were evaluated in 92 patients with hepatitis B using the Inductively Coupled Plasma − Mass Spectrometry (ICP/MS) method in the analyses. The patients were divided into the following two groups: low-high Ishak histologic activity index (HAI) (0–6: Low Histologic Activity, 7–18: High Histologic Activity) and low-high fibrosis (FS) (Fibrosis 1,1,2 and Fibrosis 3,4,5,6). The metal levels were compared between the groups. Results: The Cd concentration was found to be statistically higher in the group with low HAI scores (p = 0.019). T...