Genetic Variants of Synaptic Vesicle and Presynaptic Plasma Membrane Proteins In Alzheimer’s Disease
Erdal, Mehmet Emin | Özge, Aynur
Background: Alzheimer's disease (AD) is the most common cause of dementia in the elderly, and its etiology is still not fully understood. The aim of this study was to analyze the role of the genetic variants of two synaptic vesicle proteins (VAMP2, synapsin III) and two presynaptic plasma membrane proteins (syntaxin 1A, SNAP-25) in AD patients. We analyzed the functional polymorphisms of VAMP2, synapsin III, syntaxin 1A, and SNAP-25 genes. Method: Sixty-eight adult patients with Alzheimer disease and Seventy-eight healthy adults were included in the study. DNA was extracted from whole blood by the salting out procedure. We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. We determined alleles and the genotypes of polymorphism of VAMP2, synapsin ...
Association Analysis of the Functional MAOA Gene Promoter and MAOB Gene Intron 13 Polymorphisms in Tension Type Headache Patients
MEHMET EMİN ERDAL | AYNUR ÖZGE | NURTEN ERDAL
Abstract Background. Monoamine oxidase (MAO) enzymes play an important role in the etiology of many neurological diseases. Tension type headache (TTH) treatments contain inhibitors for selective re-uptake of serotonin and monoamine oxidase inhibitors. MAO (EC 1.4.3.4) has two isoenzymes known as MAOA and MAOB. A promoter polymorphism of a variable number of tandem repeats (VNTR) in the MAOA gene seems to affect MAOA transcriptional activity in vitro. Also, G/A polymorphism in intron 13 (rs1799836) of the MAOB gene have been previously found to be associated with the variability of MAOB enzyme activity. Objectives. The aim of our study was to investigate a possible association of monoamine oxidase (MAOA and MAOB) gene polymorphisms in tension type headache. Material and Methods. MAO gene po...