Bulunan: 109 Adet 0.002 sn
Araştırmacılar Yahya Nural
Yahya NuralECZACILIK FAKÜLTESİ TEMEL ECZACILIK BİLİMLERİ BÖLÜMÜ ANALİTİK KİMYA ANABİLİM DALI
169602

Is anti-IgE therapy effective in preventing magnesium and selenium loss in bones of mice with chronic allergic asthma?

Nural, Yahya | Erdal, Nurten | Uzun, Coşar

Objective: Chronic allergic asthma (CA) is a respiratory disease that affects millions of people worldwide. While there is evidence linking airway hyperresponsiveness and asthma to factors related to bone metabolism, the impact of asthma on bone health is not well understood. Therefore, to explore whether: (i) CA causes meaningful changes in bone magnesium (Mg) and selenium (Se) levels, and if any, (ii) anti-IgE (anti-immunoglobulin E) treatment has a protective effect against these changes. Methods: In present study used tibia bones from a previous study on CA in mice. A murine model was used to generate CA. Thirty-two BALB/c male mice were randomly divided into four equal sized groups (eight mice/group): control group (intact), CA (treated with saline (0.9% NaCl), CA+L-AIgE (100 μg of a...

Makale2023Dicle Medical Journal 2 | 0 Erişime Açık
169703

Determination of Formation Constants of Some Metal Complexes of Naphthoquinone Derivatives

Efeoglu, Cagla | Kocagöz, Gülçin | Nural, Yahya | Dincer Kaya, Fadime Nazlı

2025-12-29

169784

An X-Ray Study for Structural Characterization of cis-Bis(methyl 2-(benzoylcarbamothioyl)-3-(4-chlorophenyl)-5-methyl-4,6-dioxo-1-phenyl-octahydropyrrolo[3,4-c]pyrrole-1-carboxylate)platinum(II)

Nural, Yahya | Gemili, Muge

2025-12-29

169786

Synthesis of novel polysubstituted thiazole derivatives

Nural, Yahya | Gemili, Muge

2025-12-29

169787

Stereoselective synthesis of 2-(aminomethyl)-1-aminocyclopropanecarboxylic acid derivatives and their application in peptide design

Nural, Yahya

2025-12-29

169788

Efficient synthesis of functionalized 3-aryl-1,3-aminoalcohols

Nural, Yahya | Dondas, Haci Ali

2025-12-29

169301

New naphthoquinone thiazole hybrids as carbonic anhydrase and cholinesterase inhibitors: Synthesis, crystal structure, molecular docking, and acid dissociation constant

Efeoglu, Cagla | Selcuk, Ozge | Demir, Bunyamin | Nural, Yahya

In this study, N-[3-(3-amino-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-R-thiazol-2(3H)-ylidene]-2,6-difluorobenzamide derivatives as new 1,4-naphthoquinone thiazole hybrids were synthesized by reacting of N-[(3amino-1,4-dioxo-1,4-dihydronaphthalen-2-yl)carbamothioyl]-2,6-difluorobenzamide with various alpha-bromoketones in 76-92% yields. Their molecular structures were characterized by 1H NMR, 13C NMR, 19F NMR, FT-IR, and HRMS, and the stereochemistry of one of the hybrids was determined by single crystal x-ray diffraction study. These synthesized new compounds (3a-e) were found to be effective inhibitor molecules for cholinesterases (butyrylcholinesterase (BChE) and acetylcholinesterase (AChE)), and carbonic anhydrase I and II (hCA I and hCA II) enzymes. KI values were found to be in the ra...

169444

Novel 1,4-naphthoquinone N-aroylthioureas: Syntheses, crystal structure, anion recognition properties, DFT studies and determination of acid dissociation constants

Gemili, Müge | Nural, Yahya

In this paper, five novel 1,4-naphthoquinone N-aroylthiourea derivatives were synthesized, by the reaction of 2,3-diaminonaphthalene-1,4-dione and aroylisothiocyanates, in excellent yield (88-96%) and characterized by using FT-IR, H-1/C-13 NMR and HRMS. In addition, the molecular structure of one of the 1,4-naphthoquinone N-aroylthiourea compounds was characterized by single crystal X-ray diffraction studies. The absorption spectra of the compounds were determined in DMSO and the dyes have absorption in visible region in the range of 464-477 nm. The chemosensing ability of each of the prepared dyes was assessed by titrating them towards the anions; F-, Cl-, Br-, I- AcO-, CN-, CIO4-, H2PO4-, HSO4-, and NO3-, using spectrophotometric and H-1 NMR titration techniques in DMSO, experimentally. ...

169456

Synthesis, antimycobacterial activity, and acid dissociation constants of polyfunctionalized 3-[2-(pyrrolidin-1-yl)thiazole-5-carbonyl]-2H-chromen-2-one derivatives

Nural, Yahya

This study reports on synthesis and determination of antimycobacterial activity and acid dissociation constants of polyfunctionalized 3-[2-(pyrrolidin-l-yl)thiazole-5-carbonyl[-2H-chromen-2-one derivatives, containing thiazole, coumarin, and pyrrolidine octahydropyrrolo[3,4-c]pyrrole moieties. The products were synthesized by a cyclization reaction of 5,5-diphenylpyrrolidine N-aroylthioureas or methyl 5-substituted 4,6-dioxo-3,3-diphenyloctahydropyrrolo[3,4-c[pyrrole-lcarboxylate N-aroylthioureas and 3-(bromoacetyl)coumarin with good to excellent yield (81-97%). The compounds exhibited antimycobacterial activity against the M. tuberculosis H37Rv strain with minimum inhibitory concentration values in the range of 31.25-125 mu g/cm(3). Acid dissociation constants of the compounds were determ...

169458

Synthesis, crystal structure, DFT studies, acid dissociation constant, and antimicrobial activity of methyl 2-(4-chlorophenyl)-7a-((4-chlorophenyl)carbamothioyl)-1-oxo-5,5-diphenyl-3-thioxo-hexahydro-1H-pyrrolo[1,2-e]imidazole-6-carboxylate

Nural, Yahya | Gemili, Muge | Ulger, Mahmut

A novel bicyclic thiohydantoin fused to pyrrolidine compound, methyl 2-(4-chlorophenyl)-7a-((4-chlorophenyl)carbamothioyl)-1-oxo-5,5-diphenyl-3-thioxo-hexahydro-1H-pyrrolo[1,2-e]imidazole-6-carboxylate, was synthesized by the cyclization reaction of dimethyl 5,5-diphenylpyrrolidine-2,4-dicarboxylate and 4-chlorophenyl isothiocyanate in the presence of 4-(dimethylamino)pyridine to form methyl 2-(4-chlorophenyl)-1-oxo-5,5-diphenyl-3-thioxo-hexahydro-1H-pyrrolo[1,2-e]imidazole-6-carboxylate with concomitant addition reaction of the 4-chlorophenyl isothiocyanate in 79% yield. The structural characterization was performed by NMR, FT-IR, MS and HRMS techniques, and the stereochemistry of the compound was determined by single crystal X-ray diffraction study. In addition, the molecular structure a...

169461

Synthesis of novel immunomodulatory 1,4-disubstituted bis-1,2,3-triazoles by using click chemistry and their intracellular mechanism of action

Nural, Yahya | Acar, Irem | Yetkin, Derya | Efeoglu, Cagla | Ayaz, Furkan

In this study, six new 1,4-disubstituted bis-1,2,3-triazole compounds, N,N '-(1,2-phenylene)bis(2-(4-R-1H-1,2,3triazol-1-yl)acetamide), were synthesized with high yield (88-96 %) by using click chemistry and their molecular structures were characterized by using NMR, FT-IR, HRMS and elemental analysis techniques. Previous studies suggest anti-inflammatory and analgesic activities for different 1,2,3-triazole derivatives and in the light of those studies we aimed to examine these novel derivatives immunomodulatory activities on the mammalian macrophages. Pro-inflammatory cytokines (TNF, IL6, GMCSF and IL12p40) secretion levels were tested in the presence of bis-1,2,3-triazole compounds when the macrophages were activated with LPS. These new derivatives were able to suppress the product...

169473

Does anti-IgE therapy prevent chronic allergic asthma-related bone deterioration in asthmatic mice?

Nural, Yahya

Current evidence on the association between allergic diseases and bone metabolism indicates asthma may be a potential risk factor for bone health. Using anti-IgE has been proven effective in allergic asthma treatment with a good safety profile; however, its effects on bone health are unknown. Thus, we aimed to investigate whether: (i) chronic allergic asthma (CAA) causes any meaningful changes in bone, and if any, (ii) anti-IgE therapy prevents any CAA-induced adverse alteration. A murine model was used to study CAA. Thirty-two BALB/c male-mice were assigned into four groups (eight-mice/group): Control, CAA (treated with saline), CAA + 100 mu g of anti-IgE (CAA + 100AIgE), and CAA + 200 mu g of anti-IgE (CAA + 200AIgE) groups. After immunization, saline or anti-IgE was performed intraperit...

169317

Novel highly functionalized 1,4-naphthoquinone 2-iminothiazole hybrids: Synthesis, photophysical properties, crystal structure, DFT studies, and anti(myco)bacterial/antifungal activity

Gemili, Muge | Nural, Yahya | Ülger, Mahmut | Erat, Selma

In this paper, a series of novel highly functionalized 1,4-naphthoquinone 2-iminothiazole hybrids were synthesized via a cyclization reaction of 2,3-diaminonaphthalene-1,4-dione N-aroylthioureas and alpha-bromoketones in good to excellent yields (74-94%). The stereochemistry of one of the 1,4-naphthoquinone 2-iminothiazole products was characterized by single crystal X-ray diffraction technique. Photophysical properties of the compounds in DMSO, HAc and THF were determined by using UV-vis spectroscopy. The ground state geometries and the absorption spectra of the compounds were also determined using Density Functional Theory (DFT) and time-dependent DFT (TD-DFT) at B3LYP/631 + g(d,p) level of theory. The computed results are consistent with experimental values. An antimicrobial screening w...

169311

Synthesis, biological properties, and acid dissociation constant of novel naphthoquinone–triazole hybrids.

Nural, Yahya | Ozdemir, Sadin | Demir, Bunyamin | Yalcin, Mustafa Serkan | Erat, Selma

A series of novel 1,4-naphthoquinone-triazole hybrids, N-(3-amino-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-2-(4-R-1H-1,2,3-triazol-1-yl)acetamide, was synthesized by click chemistry in the presence of sodium ascorbate and copper(II) sulfate pentahydrate in 81-94% yield. Various biological properties of the synthesized compounds including DNA binding/cleavage, antioxidant, antibacterial and antifungal properties were evaluated. The DNA binding study was performed using dsDNA and G-quadruplex DNA. All of the compounds showed fluorescence increase in the presence of DNA, regardless of the structure. Up to 2.9 and 2.5 times fluorescence increase upon incubation with double stranded or G-quadruplex DNA was detected for 5f and 5g, respectively. The docking studies performed on dsDNA and G-quadruple...

169611

Recent advances in environmental and agricultural applications of hydrochars: A review

Al-Nuaimy, Maryam Nawfal Mahmood | Azizi, Nangyallai | Nural, Yahya | Yabalak, Erdal

Hydrochar is a carbonaceous material that is generated through the process of hydrothermal carbonization (HTC) from biomass, which has garnered considerable attention in recent years owing to its potential applications in a diverse range of fields, such as environmental remediation and agriculture. Hydrochar is produced from a diverse range of biomass waste materials and retains exceptional properties, including high carbon content, stability, and surface area, making it an optimal candidate for various enviro-agricultural applications. Moreover, it delves into the production process of hydrochar, with explicit emphasis on the optimization of certain properties during the production of hydrochar from bio-waste. Furthermore, the potential of hydrochar as an adsorbent and catalyst support fo...

169304

Comprehensive review of Carbon-based nanostructures: Properties, synthesis, characterization, and cross-disciplinary applications

Gul, Afroz | Nasir, Abir | Moses, Titus Otamayomi | Nural, Yahya | Yabalak, Erdal

Carbon has played a pivotal role in human civilization's advancement, owing to its ability to form strong bonds in various structures. Over the past three decades, numerous carbon-based nanoparticles (CBNs) have been developed through diverse synthesis processes. CBNs have been utilized in a wide range of applications, including biomedicine, catalysis, environmental remediation, and textiles. This paper provides a comprehensive study of the CBNs. The first section includes detailed descriptions of fullerenes, carbon nanotubes, graphene nanoparticles, nanodiamonds, and carbon quantum dots and their properties. Also, It provides a comprehensive overview of the different synthesis methods. The third section of this paper shows the techniques used in the characterization process and the l...

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