The Effects of Quercetin on Bone Quality in Healthy and STZ-İnduced Diabetic Rats: A Biomechanical and ICP-MS Study

Nural, Yahya

Type 1 diabetes mellitus (DM), characterized by hyperglycemia and bone loss, have been reported to be related with the increased risk of osteopenia/osteoporosis in humans (1,2). Quercetin, a naturally occurring flavonoid, has protective effects on β-cells in DM, is capable to decrease high blood glucose levels, and has been reported to be have beneficial effects on bone cells (1). Thus, the aim of the present study was to investigate the effects of QE on bone quality in healthy and STZ-induced diabetic rats. For this purpose, fifty-two, Wistar-Albino male rats (4-month; 288–396 g) were assigned randomly into four groups: sham (treated with saline), QE (treated with 50 mg/kg QE), diabetes (DM; received 45 mg/kg i.p. injection of STZ+treated with saline), and diabetes+QE (rec...