Stability constants of cobalt (II) complexes of octahydropyrrolo[3,4-c]pyrrole N-benzoylthiourea derivatives
Gemili, Muge | Nural, Yahya
It is very important to determine the stability constants of complexes, because metals are an integral part of living systems and complexes of many transition metals such as cobalt, platinum, nickel, zinc have an important place in pharmaceutical chemistry. Stability constants of complexes provide information about properties of metals and ligands, such as complex formation requests, coordination and solubility of complex molecules. It is known that aroylthiourea derivatives have been intensively studied in coordination chemistry as bidentate ligands, in analytical chemistry as sensor and in medicinal chemistry as pharmacophore group or intermediate compounds for synthesis of pharmacologically important compounds [1-3]. As a continuation of our previous work [4, in this study, we d...
Acid dissociation constants of 4-aryl-2-(pyrrolidin-1-yl)thiazole derivatives in dimethyl sulfoxide-water hydroorganic solvent”,
Gemili, Muge | Nural, Yahya
Acid dissociation constants (pKa) are among the important parameters having critical significance in the field of pharmacy, chemistry, biology, medicine etc. due to providing information related to acidity, solubility, lipophilicity, bonding to receptors, transport behavior properties of pharmaceutically important molecules, determining the optimum conditions in the development of analytical methods, and understanding the interactions between ligands and metal ions in complexes [1-3]. The thiazole and pyrrolidine scaffolds are intensively studied in drug research, and both of these pharmacophore groups exhibited a wide range of pharmacological activities such as antimicrobial, anticancer activities [3-6]. As a continuation of our previous work [3], in this study, three acid dissoci...