Chlorpromazine-tadalafil interaction leading to refractory ischemic priapism and penile prosthesis implantation: a case report
ARİCİ,CAN | BAŞARANOĞLU,MERT | ÇAYAN,SELAHİTTİN | BOZLU,MURAT | AKBAY,ERDEM
Abstract , Murat Bozlu1 and Erdem Akbay1 Background Priapism represents a rare urological emergency characterized by persistent penile erection unrelated to sexual stimulation. Although chlorpromazine-induced priapism has been documented, the synergistic interaction with phosphodiesterase type 5 inhibitors resulting in refractory cases necessitating penile prosthesis implantation constitutes a novel clinical scenario requiring comprehensive documentation. Case presentation We report a 56-year-old male who developed refractory ischemic priapism following self-administration of oral chlorpromazine for hiccups, taken 24 h after tadalafil 20 mg for erectile dysfunction. The patient had previously experienced a transient priapism episode 10 years earlier following isolated chlorpromazine use, e...
Enhancing low-temperature ethanol-selective catalytic reduction over Ag/TiO2-cordierite catalysts via cerium addition
Enhancing low-temperature ethanol-selective catalytic reduction
Resitoglu, Ibrahim Aslan
The purpose of this study is to investigate the NOx reduction activity of Ag/TiO2-Cordierite catalysts enhanced with cerium (Ce) under varying operational temperatures and engine loads. The aim is to improve the low-temperature activity of the catalyst in an ethanol-selective catalytic reduction system using real exhaust gases. During the catalyst production process, Ag and Ce were used as active components, TiO2 as the secondary support material, and cordierite as the primary carrier structure material. Catalysts with 1 wt%, 3 wt%, and 5 wt% Ce-doped Ag/TiO2/Cordierite were synthesized using the washcoating method and characterized through X-Ray Diffraction, Brunauer-Emmett-Teller analysis, and Scanning Electron Microscopy (SEM). Performance test results demonstrated that the NOx conversi...
Estimation of soil liquefaction using artificial intelligence techniques: an extended comparison between machine and deep learning approaches
Şehmusoğlu, Eyyüp Hakan | Kurnaz, Talas Fikret | Erden, Caner
This study investigates the effectiveness of various deep learning (DL) algorithms in predicting soil liquefaction susceptibility. We explore a spectrum of algorithms, including machine learning models such as Support Vector Machines (SVMs), K-Nearest Neighbors (KNN), and Logistic Regression (LR), alongside DL architectures like Convolutional Neural Networks (CNNs), Long Short-Term Memory networks (LSTMs), Bidirectional LSTMs (BiLSTMs), and Gated Recurrent Units (GRUs). The performance of these algorithms is assessed using comprehensive metrics, including accuracy, precision, recall, F1-score, receiver operating characteristic (ROC) curve analysis, and area under the curve (AUC). Cross-entropy loss is employed as the loss function during model training to optimize the differentiation...
The effects of freshwater rearing on the whole body and muscle tissue fatty acid profile of the European sea bass (Dicentrarchus labrax)
HUNT, ARZU ÖZLÜER | YILMAZ, FERBAL ÖZKAN | ENGİN, KENAN
The purpose of this study was to investigate the effect of freshwater rearing on the fatty acid profiles of the whole body and muscle tissue of the European sea bass (Dicentrarchus labrax). Half of initial fish were gradually acclimated to freshwater (FW) kept at the same temperature to salt water and grown in same conditions as their counterparts in saltwater (SW). The decrease in salinity caused an increase in the percentages of 18:1n − 9, 24:1n − 9, 18:3n − 3, 18:2n − 6 and decrease in the percentages of 14:0, 15:0, 20:0, 21:0, 20:5n − 3 and 22:6n − 3 both in the whole body and in the muscle tissue fatty acid profiles. The lipids of FW-reared fish contained significantly (P < 0.01) higher percentages of 18:2n − 6 and 18:3n − 6 than that of SW-reared fish. However, percentages of 20:5n −...
Enhanced pyramidal residual networks for single image super-resolution
Kahveci, Semih
Several super-resolution (SR) techniques are introduced in the literature, including traditional and machine learning-based algorithms. Especially, deep learning-based SR approaches emerge with demands for better quality images providing deeper subpixel enhancement. Dealing with the image enhancement task in the satellite images domain, a new SR method for single image SR, namely Enhanced Deep Pyramidal Residual Networks, is introduced in this study. The proposed method overcomes the potential instability problem of Enhanced Deep Residual Networks for Single Image Super-Resolution (EDSR) approach by gradually increasing the feature maps depending upon Pyramidal Residual Networks architecture. The EDSR itself is a good algorithm in the SR domain. However, it has a strict structure for incre...
Thermostable alkaline protease produced by an Aspergillus niger strain
Coral, Mutlu Nisa Ünaldı | Coral, Gökhan
A thermostable alkaline protease was isolated from the Aspergillus niger Z1 strain in a liquid Czapek Dox medium, containing casein (1% w/v) as the sole nitrogen source. Enzyme extract was subjected to electrophoresis in SDS-polyacrylamide gel. Two protein bands were seen on polyacrylamide gel. Active enzyme was visualized in a zymogram and protease activity exhibited a molecular mass of 68 kDa on SDS-polyacrylamide gel. The optimum pH for activity was found to be 9.0. The temperature optima of the enzyme was found to be 40 °C at pH 9.0 and it remained stable up to 90 °C, with 48.4% of the original activity retained after heat treatment at 90 °C for 15 min. Proteolytic activity was inhibited by PMSF, but slightly inhibited by SDS.
Effects of dietary selenium of organic form against lead toxicity on the antioxidant system in Cyprinus carpio
YILMAZ, FERBAL ÖZKAN | HUNT, ARZU ÖZLÜER | YALIN, SERAP
In this study was evaluated potential protective effect of organic selenium (Se) on heavy metal stress induced by lead (Pb) in Cyprinus carpio. For this reason, C. carpio was exposed to sublethal concentration of Pb (1.5 mg/L Pb(NO3)2) for 14 days. The fish were fed a basal (control; measured 0.55 mg/kg Se) diet or a basal diet supplemented with 2.50 mg/kg (measured 2.92 mg/kg Se) organic Se (Sel-Plex®) during the experiment period. The variations in glutathione peroxidase (GSH-Px), glutathione S-transferase (GST) activities, and levels of reduced glutathione (GSH) with malondialdehyde (MDA) in liver and brain tissues of C. carpio were investigated in experimental groups. GSH levels in liver and brain tissues were significantly decreased by exposure to Pb. GST activity was significantly in...
The protective role of ascorbic acid (vitamin C) against chlorpyrifos-induced oxidative stress in Oreochromis niloticus
YILMAZ, FERBAL ÖZKAN | HUNT, ARZU ÖZLÜER | YALIN SERAP
Ability of ascorbic acid (vitamin C) to attenuate oxidative damage was evaluated in liver and brain tissues of Oreochromis niloticus (O. niloticus) experimentally exposed to sublethal concentrations of chlorpyrifos (CPF). O. niloticus was exposed to sublethal concentrations of CPF at 12 μg/L (CPF1) and 24 μg/L (CPF2) for 96 h. The fish of vitamin C (Vit C) and CPF2 + Vit C groups were fed with Vit C supplemented diet (200 mg Vit C/100 g feed). A significant increase in thiobarbituric acid-reactive substances (TBARS) level (P < 0.05) was observed in brain of CPF-exposed fish although liver TBARS level was not changed compared to control group. This result showed that lipid peroxidation (LPO) was elevated in brain of fish exposed to CPF. Glutathione peroxidase (GSH-Px) activity in liver and ...
Plasmid mediated heavy metal resistances in Enterobacter spp. isolated from Sofulu landfill, in Adana, Turkey
Coral, Mutlu Nisa Ünaldı | Coral, Gökhan
A total of 15 Enterobacter spp. were isolated from water drainage near the landfill in Sofulu village in Adana and were characterised on the basis of morphological, cultural and biochemical characteristics. The Maximum Tolerable Concentrations of cadmium, copper, chromium and nickel for growth were used to determine metal tolerance of the isolated strains. Among the resistant strains used in this study, Ent-5, Ent-7 and Ent-15 were found to have plasmid resistance to copper and nickel. One resistant strain, Ent-5, functioned as a donor of copper resistance. Copper resistance transferred from Ent-5 to Escherichia coli AB3505 at a frequency of approximetely 2.7 x 10-5 per recipient cell. Transformant strain had one plasmid with the same molecular weight donor strain’s plasmid. These isolates...
Artificial intelligence-based prediction of treatment failure and medication nonadherence in overactive bladder management
BAŞARANOĞLU,MERT | TAŞDEMİR,İSA KAMİL | AKBAY,ERDEM | DORUK,HASAN ERDAL
Abstract , Background Overactive bladder management presents significant challenges, with treatment failures and medication non-adherence posing substantial barriers to patient outcomes. Early prediction of these challenges could enable timely interventions and treatment modifications. Objectives To develop and validate an artificial intelligence-based prediction model for early identification of treatment failure and medication non-adherence in overactive bladder patients, with specific focus on different pathological subgroups including diabetic neuropathy. Methods In this single-center retrospective study (January 2018–April 2025), we analyzed data from 285 patients with overactive bladder. We developed and validated artificial intelligence models using comprehensive clinical parameters...
From digital assistants to clinical partners: revolutionizing pediatric urology through large language model-powered decision support and patient education
BAŞARANOĞLU,MERT | AKBAY,ERDEM | ERDEM,ERİM
Abstract Background Large language models (LLMs) demonstrate increasing potential in healthcare applications, yet their clinical utility in specialized pediatric medicine remains inadequately characterized. This study evaluated LLM performance in pediatric urology to establish evidence-based implementation frameworks. Methods We conducted a two-phase evaluation of thirteen current-generation LLMs between January and April 2025. Phase 1 assessed clinical decision support using 180 standardized cases stratified by complexity (126 routine, 54 complex) based on European Association of Urology pediatric guidelines. Phase 2 evaluated patient education effectiveness across four common pediatric urological conditions. Performance was measured using mathematical similarity metrics and standardized ...
The effect of different dwell times at a constant pelletization pressure of 6 GPa on superconducting properties of Bi1.8Sr2Ca1.1Cu2.1Oy ceramics
Sugözü, Banu | Sugözü, İlker
In this study, the physical and magnetic properties of Bi1.8Sr2Ca1.1Cu2.1Oy superconductors kept in different dwell times (1, 6, and 12 h) at a constant pelletization pressure of 6 GPa in the pressing step as prepared by standard solid-state reaction method are reported. The X-ray diffraction data shows that all samples have a tetragonal crystal structure with predominant Bi-2212. SEM micrographs for all samples predominately show plate-like grain structure, indicating the presence of Bi-2212 phase. Both Tc (onset) and Tc (offset) significantly increase with increasing dwell time. M–H measurements were performed at T = 10 and 25 K, respectively. In addition, Jc values of the samples were calculated from their magnetic hysteresis loops using the Bean’s model. It has been found that Jc in th...
H2O2 Sensing on Co3O4-s-rGO Modified with Ni Nanodots
Rukan Suna Karatekin | Meltem Kahya Düdükcü | Gülşen Avcı
In this paper, Ni@Co3O4-s-rGO was synthesized and constructed as a non-enzymatic sensor to detect hydrogen peroxide(H2O2). The prepared sample was characterized using SEM–EDX, UV–vis, XRD, and Raman spectroscopy. In 0.1 Mphosphate-buffered saline (PBS), the fabricated Ni@Co3O4-s-rGO amperometric sensor demonstrated a high sensitivity of 160.3 μA·mM⁻1 towards H2O2 within the linear detection range of 1 to 2000 μM. The detection limit was also determinedas 3.6 μM. Furthermore, the Ni@Co3O4-s-rGO catalyst demonstrated high selectivity towards H2O2,even in the presenceof common interferents. The enhanced electrochemical sensing ability of the catalyst is attributed to the synergy of three factors: the relatively large electrode active area, the high electrical conductivity, and the electron mo...
Experimental Investigation on the Friction and Wear Characteristics of Palm Seed Powder Reinforced Brake Pad Friction Composites
Sugözü, Banu
In this research work, palm seed power (0–9 wt%, step of 3%; four composites sample, namely P0, P3. P6, P9) were used to reinforce master batch of friction composite materials containing phenolic resin binder, steel swarf fibre, cashew, alumina, graphite, copper and zinc. The fabrications were as per standard industrial practice via hot compression moulding route. Thereafter, samples were cut and characterized for their tribological characteristics on specifically designed braking dynamometer using grey cast iron disc as per TS 555 and TS 9076 standards. Physical and mechanical properties such as hardness and density of the samples were also determined. Further, multi-criteria-decision-making like Preference Selection Index methods are used to ascertain ranking of material alternatives bas...
Some properties of thermostable xylanase from an Aspergillus niger strain
Coral, Mutlu Nisa Ünaldı | Coral, Gökhan
A thermostable xylanase was isolated from an Aspergillus niger wild type strain in a liquid Czapek Dox medium, containing oat spelts xylan as the sole carbon source. The molecular mass of the enzyme was estimated to be about 36 kDa by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The optimum pH for activity was found to be 7.5. The temperature optimum of the enzyme was found to be 60 °C at pH 7.5. The enzyme remained stable up to 100 °C, yet lost about 50% of its activity after 15 min at this temperature.
Keratinolytic activity of Streptomyces strain BA7, a new isolate from Turkey
Coral, Mutlu Nisa Ünaldı | Coral, Gökhan
A wild type Streptomyces strain BA7 which was isolated from soil, showed a high keratinolytic activity when cultured on native feather medium. Optimum keratinolytic activity was observed at 50 ºC and pH 8.5 when using fluid supernatant obtained from aerated culture of this organism. The keratinolytic activity was completely stable (100%) between 30 and 60 ºC. The molecular weight of crude enzyme was estimated by SDS-PAGE about 44000 Da. The degradation of intact feathers by Streptomyces sp. BA7 keratinase was obtained after 24 h of incubation at 50 ºC. Keratinolytic activity was partially inhibited by 1,10-phenanthroline, but slightly inhibited by CaCl2, ZnCl2, and SDS. In addition keratinolytic activity was enhanced by DMSO, EDTA, Triton-X 100 and sodium sulphite. Streptomyces strain BA7 ...