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American Journal of Obstetrics and Gynecology1
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Archives of Medical Research1
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Archives of Oral Biology1
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Environmental Pollution1
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European Journal of Obstetrics & Gynecology and Reproductive Biology1
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European Psychiatry1
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Journal of Clinical Neuroscience1
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Journal of Investigative Dermatology1
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Journal of Molecular Structure1
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Journal of tissue viability1
Tardive dyskinesia is not associated with the polymorphisms of 5-HT2A receptor gene, serotonin transporter gene and catechol-o-methyltransferase gene
Erdal, Mehmet Emin
Background. – The pathophysiology of tardive dyskinesia (TD) is not completely understood. Aim. – To assess the relationship of TD with 5-HT2A receptor gene, serotonin transporter gene (5 HTT), and catechol-o-methyltransferase (COMT) gene polymorphisms. Method. – Our study comprised 111 unrelated subjects who strictly met DSM-IV criteria for schizophrenia and 32 TD, and 79 healthy unrelated controls; all the subjects were of Turkish origin. The analyses of 5-HT2A receptor gene, 5 HTT gene, and COMT gene polymorphisms were performed using polymerase chain reaction (PCR) technique. Results. – The polymorphisms of these genes were not significantly different between the schizophrenic patients, TD and control subjects. Conclusion. – Our findings indicated that 5-HT2A receptor gene, 5 HTT gene,...
Exploring bisbenzimidazole-chalcone hybrid compounds: Dual-action as antibacterial agents targeting biofilm formation and E. coli DNA gyrase inhibition
ADAR ERCAN | ÖKSÜZ ZEHRA | DÖĞEN AYLİN | ALGÜL ÖZTEKİN
The emergence of antibiotic-resistant pathogens has reduced the efficacy of current antimicrobial therapies, emphasizing the need for new therapeutic agents. This study presents the design, synthesis, and evaluation of bisbenzimidazole-chalcone hybrid compounds as potential antimicrobial agents. These compounds were tested for their antimicrobial activity against eleven common pathogens, as well as their ability to inhibit biofilm formation and eradicate preformed biofilms in Escherichia coli. Compounds EA1, EA3, EA4, and EA5 demonstrated antibacterial activity against E. coli comparable to ampicillin (31.25 μg/mL) and outperformed the other tested compounds. Notably, EA4 and EA5 inhibited biofilm formation at sub-MIC concentrations and effectively eradicated preformed biofilms, as ...
PPAR-g2 Pro12Ala polymorphism is associated with weight gain in women with gestational diabetes mellitus
Tok, Devrim | Erdal, Mehmet Emin
Objective: The polymorphisms of peroxisome proliferator–activator receptor-g2 (PPAR-g2) have been suggested to affect glucose metabolism and weight gain. Both conditions show great variations during pregnancy that makes pregnancy a suitable condition to detect any metabolic abnormalities related to PPAR-g2 polymorphisms. The objective of this study is to investigate the prevalence and metabolic impacts of PPAR-g2 polymorphism in control pregnant women and in patients with gestational diabetes mellitus (GDM). Methods: In this case-control study, anthropometric and metabolic variables of 100 non-diabetic pregnant women and of 62 women who were diagnosed as having GDM according to 100 g oral glucose tolerance test (OGTT) were compared on the basis of PPAR-g2 polymorphism by univariate analysi...
Association of insulin receptor substrate-1 G972R variant with baseline characteristics of the patients with gestational diabetes mellitus
Tok, Devrim | Erdal, Mehmet Emin
Objective: Insulin receptor substrate-1 (IRS-1) expression and tyrosine phosphorylation is decreased during pregnancy. Pregnancy may be a suitable condition to detect any abnormalities related to IRS-1 polymorphisms. Therefore, we aimed to investigate the prevalence and metabolic impacts of IRS-1 G972R polymorphism in patients with gestational diabetes mellitus (GDM). Study design: Anthropometric and metabolic variables of 62 women who were diagnosed as having GDM according to 100 g oral glucose tolerance test were compared on the basis of IRS-1 polymorphism by univariate analysis of covariance. Results: Patients with IRS-1 G972R were more obese at the beginning of pregnancy, had higher serum fasting insulin and glucose levels. Weight gain during pregnancy and insulin and glucose levels af...
Assessment of biological effects of environmental pollution in Mersin Bay Turkey northeastern Mediterranean Sea using Mullus barbatus and Liza ramada as target organisms
Doruk Yılmaz, Mustafa Kalay, Erdem Dönmez, Nejat Yılmaz
The increasing emphasis on the assessment and monitoring of marine ecosystems has revealed the need to use appropriate biological indicators for these areas. Enzyme activities and histopathology are increasingly being used as indicators of environmental stress since they provide a definite biological end-point of pollutant exposure. As part of an ecotoxicological assessment of Mersin Bay, EROD enzyme activity and histopathological response in selected organs and tissues of two species of fish, Mullus barbatus (red mullet) and Liza ramada (thinlip grey mullet), captured from area were examined. Pollutant (Organochlorines (OC), alkylphenols (APs) and BPA) levels and biomarker responses in tissue samples were evaluated together for their potential to alter the metabolism and cellular aspects ...
Lack of Effect of Extremely Low Frequency Electromagnetic Fields on Cyclin-Dependent Kinase 4 Inhibitor Gene p18INK4C in Electric Energy Workers.
Erdal, Nurten | Erdal, Mehmet Emin
Background. Long-term exposure to extremely low frequency magnetic fields (ELF-MFs) may be a risk factor for human cancer. One mechanism through which ELF-MFs could influence neoplastic development is the deletion/mutation of cancer-related genes. Cellular proliferation follows an orderly progression through the cell cycle, which is governed by different cyclins and cyclin-dependent kinase inhibitors (CDKIs). The putative tumor suppressor gene p18INK4C encodes a specific inhibitor of cyclin D-cyclin-dependent kinase 4 inhibitor complexes having an important role in cell-cyclin regulation. It has been found to be deleted/mutated in a variety of human cancers. Therefore, this study is to investigate whether or not long-term extremely low frequency electromagnetic field exposure may be a risk...
Multi-source assessment of drought risk in Lake Eğirdir under climate change
Yiğit, Abdurahman Yasin
In this study, shoreline changes in Lake Eğirdir, Türkiye, were investigated over a 34-year period (1990–2024) through the application of remote sensing, GIS-based coastal analysis (DSAS- Digital Shoreline Analysis System) and statistical trend methodologies. Landsat images and meteorological data are analysed together to evaluate the relationship between climate variability and shoreline dynamics. The findings show that there is a significant shoreline erosion, especially in the northern and western regions, with the End Point Rate (EPR) values reaching −23.6 m/year and Linear Regression Rate (LRR) values reaching −11.23 m/year. According to the results of statistical trend analysis methods (Mann-Kendall-MK and Spearman Rho-SR) and Innovative Trend Analysis (ITA) methods (sorted and unsor...
Virtual reality visualisation of automatic crack detection for bridge inspection from 3D digital twin generated by UAV photogrammetry
Yiğit, Abdurahman Yasin
This research develops a UAV photogrammetry methodology to generate 3D digital twins (DT) of the Elvanlı Bridge in Mersin, Turkey. These DTs are then analyzed using advanced image processing algorithms for automatic crack detection. The identified cracks were incorporated into the 3D model, creating a DT to damage-augmented digital twins (DADT). Subsequently, the DADT was rendered in virtual reality, offering an interactive alternative solution with remote access to on-site structural visual inspections in a digital environment. This approach has increased the objectivity and efficiency of inspections in the digital environment. The results demonstrate the potential of this integrated approach to enhance the accuracy and reliability of bridge inspections, reduce operational costs, and prov...
Use of honey in diabetic foot ulcer: Systematic review and meta-analysis
Ebru Yildiz Karadeniz | Emine Kaplan Serin
Objective The aim of this study was to evaluate the role of honey dressing as an effective intervention for diabetic foot wound management and to provide a reliable basis for future clinical study. Materials and methods We analyzed an assortment of randomized controlled trial (RCT), quasi-experimental and cross-sectional studies. We selected RCTs and quasi-experimental studies for meta-analysis. We only conducted a descriptive analysis for observational studies. Results The meta-analysis showed that honey used effectively reduces wound recovery time and rate, incurred pain, hospital stay, and accelerates granulation in DFU wounds. Conclusions Our findings suggest that honey effectively promotes healing in DFU. Further research is needed to elucidate these findings so that this form ...
The A218C polymorphism of tryptophan hydroxylase gene and migraine
Erdal, Nurten | Erdal, Mehmet Emin
Objective: To determine the significance of the A218C polymorphism of the tryptophan hydroxylase (TPH) gene in migraine. Methods: Fifty-nine migraineurs and 62 healthy controls were included in the study, and polymerase chain reaction – restriction fragment length polymorphism assays were used to determine TPH A218C polymorphism. Results: There was no association between TPH gene polymorphism and gender, family history of migraine and epilepsy, or aura. There was no significant difference between the allele frequencies of both groups (p > 0.05). A significant difference was found between the genotypes of the migraineurs and controls regarding the AA genotype. Homozygosity for the C allele or heterozygosity for the A or C was not associated with the occurrence of migraine (p > 0.05), but ho...
Extracellular Matrix Protein 1 Gene (ECM1) Mutations in Lipoid Proteinosis and Genotype-Phenotype Correlation
Erdal, Mehmet Emin
The autosomal recessive disorder lipoid proteinosis results from mutations in extracellular matrix protein 1 (ECM1), a glycoprotein expressed in several tissues (includingsk in) and composed of two alternatively spliced isoforms, ECM1a and ECM1b, the latter lackinge xon 7 of this 10-exon gene (ECM1). To date, mutations that either a¡ect ECM1a alone or perturb both ECM1 transcripts have been demonstrated in six cases. However, lipoid proteinosis is clinically heterogeneous with affected individuals displayingdi¡ ering degrees of skin scarringand in¢ltration, variable signs of hoarseness and respiratory distress, and in some cases neurological abnormalities such as temporal lobe epilepsy. In this study, we sequenced ECM1 in 10 further unrelated patients with lipoid proteinosis to extend geno...
Interleukin-1 receptor antagonist gene polymorphism, adverse pregnancy outcome and periodontitis in Turkish women
Erdal, Mehmet Emin
Objective: The aim of this study was to determine associations between interleukin (IL)-1A (+4845), IL-1B (+3954), and IL-1 receptor antagonist (RN) variable number tandem repeat polymorphisms and adverse pregnancy outcomes and periodontitis in a Turkish women. Design: A total of 156 patients, including 64 women with normal birth outcome (NB) and 92 women with preterm/low birth weight outcome (PLBW) were included in this case-control study. Within 24 h after labor, maternal demographic characteristics and clinical periodontal parameters were recorded. The distribution and genotype frequencies of IL-1 were analyzed with polymerase chain reaction-restriction fragment length polymorphism assay. Statistical analyses were carried out for clinical periodontal parameters, genotype frequencies, an...