Synthesis and Crystal Structure of Cyclic- and Bicyclic-Aminocarbothioyl Pyrrolidines From α-Aminoacid Ester

Nural, Yahya | Döndaş, Hacı Ali

Imine-azomethine ylides- 1,3-Dipolar cycloaddition cascades reactions fumishing pynolidine compounds derived from amine and cı-aminoasit ester were reported and reviewed by Grigg e, a//. This cascade chemistry have been applied to provide a series of peptidomimetics and nikkomycin analogous2. It has been reported that carbothioyl compounds and their metal complexes show a wide range of biological activitiesr. In this study, continuation of our previous worka, some novel cyclic- and bicyclic-aminocarboüioyl pynolidines (1,2) were prepared fiom substituted pyrrolidines, derived from conesponding cı -aminoasit ester vıa metal catalysed imine-azomethine ylides- 1,3-Dipolar Cycloaddition reaction in excellent yield. The strucfures of prepared novel compounds were determined by NMR, , FT...