Synthesis of functionalized 1,3-oxazinan-2-ones and piperidine-2,4-dione derivatives

Nural, Yahya | Dondas, Haci Ali

1,3_oxazinanone derivatives show a range of biological activities such as antıbacterial [,1], anti-inflamm atory |2| and anti-HlV [3] properties, and are also usefuI compounds for further synthetic transformations to natura| products [4] or biologically relevant compounds [5]. Piperidine-2,4-dione derivatives are the key intermediates for synthetic transformations to 6-9ryl4-hydroxypiperidin-2-ones [6] and 4-hydroxypipecolic acids [7] ln this study, diastereoselective electrophile-induced cyclocarbamation of N_protected benzyl N-(1-pheny1-3-butenyl)carbamates towards an efficient synthesis o{ o-functiona|ized 4-aryl1,3-oxazinan-2-ones and their application in the synthesis of 6-arylpiperidine-2,4 _ diones were repoied [8].