Objective This study was conducted to determine the effect of reiki and acupressure on pain, anxiety, and vital signs during femoral sheath removal in patients undergoing percutaneous coronary intervention. Methods The study, which was conducted as a prospective randomized controlled study, was carried out with 84 patients: reiki group (n = 28), acupressure group (n = 28), and control group (n = 28). Twenty minutes before the femoral catheter was extracted, 18 minutes of reiki was applied to the seven chakra regions in the reiki group, and 20 minutes of acupressure was applied to the LI4, HT7, and PC6 points in the acupressure group. The control group received standard care. All three groups were given the assessment with Visual Analog Scale, Spielberger State Anxiety Scale, and 5 minutes ...