Possible Association of FAS and FASLG Polymorphisms with the Risk of Idiopathic Azoospermia in Southeast Turkey

Erdal, Mehmet Emin | Ay, Özlem İzci

To investigate the association of the genetic variants of FAS/FASLG cell death pathway genes in male infertility, we genotyped the FAS - 670A/G, - 1377G/A, and FASLG - 124A/G single-nucleotide polymorphisms (SNPs) by real-time polymerase chain reaction in 108 infertile men with idiopathic azoospermia and in 125 proven fertile controls. The distribution of genotypes and alleles for SNPs at FAS - 1377G/A and FASLG - 124A/G loci were determined not to be statistically different between the case and control groups. However, the genotype frequencies of SNPs, FAS - 670AA and FAS - 670AG, were found to be significantly different between the case and control groups. Whereas the FAS - 670AA genotype might be regarded as a higher predisposition for idiopathic azoospermia, FAS - 670AG could be interp...