Association of the -1438 G/A and 102 T/C Polymorphism of the 5-Ht2A Receptor Gene with Irritable Bowel Syndrome 5-Ht2A Gene Polymorphism in Irritable Bowel Syndrome

Erdal, Mehmet Emin | Yazıcı, Mustafa Kemal

Goals: The aim of this study is to investigate whether there were any association between the 102 T/C and −1438 G/A polymorphisms of the 5-HT2A receptor gene and IBS, and abdominal pain, anxiety and depression. Background: Genes involved in serotonin (5-HT) metabolism are good candidates for the pathogenesis of irritable bowel syndrome (IBS). Recently, a silent polymorphism in the 5-HT2A receptor gene was identified that is defined by a T to C transition at position 102. Also, a novel G to A base change at position −1438 of the promoter region has been detected in 5-HT2A receptor gene. Study: Fifty-four patients with IBS diagnosed according to the Rome 1 criteria and 107 healthy individuals were included in the study. PCR was used to amplify a 468-bp (G→A) and 342-bp (T→C) fragment of geno...