Liver tissue trace element levels in HepB patients and the relationship of these elements with histological injury in the liver and with clinical parameters

Karayakar, Fahri | Çolak, Tahsin

Aim: In this study, the relationship of liver tissue trace element concentrations with hepatitis B disease and the effects of several environmental factors were analysed. Method: The liver tissue concentrations of Al, Fe, Cd, Mn, Cr, Cu, Pb, Ni, Zn, Ag, and Co were evaluated in 92 patients with hepatitis B using the Inductively Coupled Plasma − Mass Spectrometry (ICP/MS) method in the analyses. The patients were divided into the following two groups: low-high Ishak histologic activity index (HAI) (0–6: Low Histologic Activity, 7–18: High Histologic Activity) and low-high fibrosis (FS) (Fibrosis 1,1,2 and Fibrosis 3,4,5,6). The metal levels were compared between the groups. Results: The Cd concentration was found to be statistically higher in the group with low HAI scores (p = 0.019). T...