Significance of serotonin transporter gene polymorphism in migraine
Erdal, Mehmet Emin | Barlas, İbrahim Ömer
ObjectiÕe. To elucidate significance of the serotonin transporter gene ŽSTG. polymorphism in migraine, and to address the polymorphic patterns of STG, both in the migraineurs and healthy people in this country. Study design. A PCR study of STG in 52 migraineurs and 80 healthy controls. Methods. Using the PCR technique, STG polymorphism was studied in the DNA obtained from leukocytes of the patients and healthy controls. Polymorphism of the two regions ŽVNTR and 5-HTTLPR. of STG was assessed. Results. VNTR STin 2.10 and STin 2.12 alleles were detected in migraineurs and healthy controls. Both homozygous and heterozygous STin 2.10 allele predominated in the migraine group Ž ps0.01., while STin 2.12 allele was more frequent in the healthy controls Ž ps0.02.. There was no relationship between ...
Association of the T102C polymorphism of 5-HT2A receptor gene with aura in migraine
Erdal, Mehmet Emin
ObjectiÕe: To find out the significance of the 5-HT2A receptor gene polymorphism in migraine. Study design: A PCR study in which 61 migraineurs and 44 healthy controls were included. Methods: The T102C polymorphism of the 5-HT2A receptor gene was studied. The results of the migraineurs and controls were compared. The relationship between the gene polymorphism and aura was also assessed. Results: The representations of the 5-HT2A genotypes were similar in migraineurs and controls Ž p)0.05. as well as in the male and female migraineurs Ž p)0.05.. The family history of migraine did not associate with 5-HT2A receptor gene polymorphism Ž p)0.05.. There was a significant relationship between the presence of CrC genotype and migraine with aura Ž ps0.02. while CrT and TrT genotypes were over repre...