Mineralization of Hydrochlorothiazide using Hydrogen Peroxide in Subcritical Water
Yabalak, Erdal | Görmez, Özkan | Nural, Yahya
In this paper, we investigated the mineralization of hydrochlorothiazide, a diuretic drug which is used for the treatment of hypertension, using H2O2 as the oxidizing agent in subcritical water as a medium. Response surface methodology was applied to optimize experimental parameters such as temperature, treatment time, and concentration of the oxidizing agent. 85.22% of TOC removal was obtained at 403 K, 80 mM of hydrogen peroxide and 147.3 min. The reliability of the performed method was evaluated by ANOVA and the theoretical equation of TOC removal of hydrochlorothiazide was proposed. F and p values of the model were determined as 62.88 and lower than 0.0001, respectively.
Synthesis and Determination of Acid Dissociation Constants in Dimethyl Sulfoxide–Water Hydroorganic Solvent of 5,5-Diphenylpyrrolidine N-Aroylthiourea Derivatives
Nural, Yahya
Novel 5,5-diphenylpyrrolidine N-aroylthioureas, containing 4-methylbenzoyl, 2- chlorobenzoyl, 2,4-dichlorobenzoyl, and 2-naphthoyl were synthesized, and their structural analyses were performed using 1H Nuclear Magnetic Resonance (NMR), 13C NMR, Fourier transform infrared spectroscopy (FT-IR), mass spectrometry (MS), and high-resolution MS (HRMS) techniques. The acid dissociation constants of the 5,5-diphenylpyrrolidine Naroylthiourea derivative compounds were determined using Hyperquad computer program for data obtained using potentiometric titration method in 25% (v/v) dimethyl sulfoxide–water hydro-organic solvent in the presence of 0.1 molL 1 ionic strength of NaCl and in the acidic medium at 25±0.1 °C, using sodium hydroxide base as a titrant. Two acid dissociation constants ...
Synthesis and Determination of Acid Dissociation Constants of Bis-Acyl Thiourea Derivatives
Efeoglu, Cagla | Tiken, Şit | Nural, Yahya
N,N'-((dodecane-1,12-diylbis(azanediyl))bis(carbonothioyl))bis(4-nitrobenzamide) 5 and N,N'-((dodecane-1,12-diylbis(azanediyl))bis(carbonothioyl))bis(3-nitrobenzamide) 6 as bis acyl thiourea derivatives were synthesized and their molecular structures were characterized using 1H NMR, 13C NMR, COSY, DEPT, HMQC, FT-IR, and HRMS techniques. The acid dissociation constants (pKa) of the bis-acyl thiourea derivatives 5, 6 were determined potentiometrically and spectrophotometrically. The pKa values of products 5, 6 were determined in 50% (v/v) dimethyl sulfoxide–water hydro-organic solvent in the presence of 0.1 molL1 ionic strength of NaCl and in the acidic medium at 25±0.1 °C, and two pKa values were calculated for each compound with the HYPERQUAD computer program using the data obtai...