Simple and convenient preparation of some bicyclic alcohols and epoxide derivatives promising antibiotic activities of rac dimethyl 3 8 dioxatricyclo 3 2 1 02 4 oct 6 ene 6 7 dicarboxylate

Yılmaz Özgür, Şimşek Kuş Nermin

The biological activity of alcohol and epoxide groups containing bicyclic skeletal structures was investi- gated in terms of antibiotic and toxic effects at cellular level. The present protocol, which utilizes readily available starting materials and mild reaction conditions, provides an attractive approach to a series of functionalized bicyclic alcohol and epoxide derivatives with promising biological applications. In this protocol, while some of the bicyclic compounds were synthesized as in the literature, the other bicyclic compounds were synthesized by new synthetic methods. The antibiotic and toxic properties of the syn- thesized bicyclic compounds were investigated, and some of their biological activities were tested in prokaryotic and eukaryotic systems. (rac)-Dimethyl 3,8-dioxatric...