Indications of the SERPINE 1 variant rs1799768’s role in anti-VEGF therapy resistance in neovascular age-related macular degeneration
Zuhal Altintas
Age-related macular degeneration (AMD) is a retinal disease prevalent in the elderly population, with two main subtypes: dry (non-exudative) and neovascular (wet or exudative). Neovascular AMD (nAMD) has a more debilitating prognosis than dry AMD, making it the third leading cause of blindness. Intravitreal injections of anti-vascular endothelial growth factor (IV anti-VEGF) are the most effective and widely accepted treatment for nAMD. However, a significant number of nAMD patients exhibit suboptimal responses to IV anti-VEGF therapy, with the underlying mechanisms not yet fully understood. We hypothesized that genetic polymorphisms associated with blood hypercoagulation may also contribute to suboptimal responses to IV anti-VEGF therapy. This study recruited 20 nAMD patients, who were di...
Decoding budget awareness: A multivariateanalysis of generation Z undergraduates
Yüksel, Cihan
Understanding public finance and budget processes has become increasingly import-ant for the younger generation in recent years. This knowledge enables Generation Zto participate more effectively in democratic life as informed citizens. However, thereis limited research on Generation Z’s awareness of public budgets in the existingliterature. Therefore, the study addressed a significant gap in the public finance litera-ture. We aimed to examine the determinants influencing the state budget awarenessof Generation Z undergraduates by using the survey: “Citizens’ Budget Awarenessand Effective Factors”. Data was collected from 3,972 undergraduates across alldisciplines enrolled in four Turkish state universities between December 2023 andApril 2024. We conducted a multiple linear regression anal...