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11th International Symposium on Pharmaceutical Sciences (ISOPS-11)2
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1st International Conference on Green Chemistry and Sustainable Technologies (GCSTI 2015)2
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7th International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2024)2
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Anatolian Conference on Synthetic Organic Chemistry ACSOC II2
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The 17th Sigma-Aldrich Organic Synthesis Meeting2
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Türk Dil Kurumu2
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10th Aegean Analytical Chemistry Days1
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2nd Cilicia International Symposium On Engineering And Technology (CISET)1
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4th International Bahçeşehir University (BAU) Drug Design Congress1
Efficient synthesis of functionalized 3-aryl-1,3-aminoalcohols
Nural, Yahya | Dondas, Haci Ali
2025-12-29
Yapay Zekâ ve Siyasal İletişim: Fırsatlar ve Riskler Üzerine Bir Değerlendirme
Yegen, Ceren
Makine öğrenmesi ve yapay zekâ ile birlikte yeni teknolojilerin aracıladığı ile uygulamalarla tanışan toplumların teknoloji ile ilişkisi, bu çerçevedeki gelişmeler ışığında sürekli güncellenmektedir. İnsana özgü yeteneklerin programlanmış, özellikli ve suni şekilde ortaya koyulması, beklentiler gibi kaygıları da beraberinde getirmiştir. Yapay zekâ alanındaki süregelen gelişmeler ve kullanım amaçlarının çeşitlenmesi temelinde bir belirsizlik gözlendiğinden, etik ilkelerin zorunluluğuna da dikkat çekilmektedir. Dolayısıyla yapay zekâ etiğine yönelik artan bir ilgi ve araştırma gözlenmektedir. Bununla birlikte, teknoloji ve siyaset arasındaki ilişki de yapay zekâdan etkilenmekte, yapay zekânın siyasal iletişim alanına girdiği görülmektedir. Özellikle dezenformasyon, sahte içerikler üzerinden ...
Synthesis of novel aminocarbo-N-thiol pyrrolidine derivatives and their antituberculosis activities
Poyraz, Samet | Nural, Yahya | Ülger, Mahmut | Belveren, Samet | Gemili, Müge | Erşen, Duygu | Serin, Mehmet Sami | Döndaş, Hacı Ali
Pyrrolidine and aminocarbothiol pyrrolidine derivatives have been extensively studied during the last decade due to possessing biological and pharmacological properties such as antifungal, antibacterial and antimalarial activity [1-3]. Pyrrolidine ring also have important place in drug research and this structure is present in many alkaloids and drug molecules [1].
Environmentally friendly synthesis of N-thiazole-pyrrolidine derivatives in supercritical carbon dioxide and subcritical water
Nural, Yahya | Yabalak, Erdal | Gemili, Müge | Gizir, Ahmet Murat | Döndaş, Hacı Ali
Supercritical carbon dioxide (scCO2) is widely used in several academic discipline as environmentally friendly fluid. Studies related to scCO2 have gained importance, due to having some properties such as low toxicity and non-flammability [1]. Subcritical water is defined as water which heated between 100 and 374 °C and pressurized high enough to maintain it in the liquid state [2] Solvent properties which related to polarity of water is depend on its temperature. As a result both polar and non-polar organics can easily dissolve in subcritical water [3]. Thiazole [4] and pyrrolidine [5], five-membered heterocyclic structures, have been intensively studied in medicinal chemistry because of their heterocyclic moieties in which present in the many bioactive molecules and alkal...
Antiapoptotic Effect of Pyrrolidine Derivatives Bearing Indole Ring As Substituted Moiety on MCF-7 Cells
Nural, Yahya | Canacankatan, Necmiye | Belveren, Samet | Poyraz, Samet | Gemili, Müge | Yetkin, Derya | Kibar, Kezban | Yılmaz, Ş. Necat | Döndaş, Hacı Ali
Background: The pyrrolidine and indole ring system found in the structure of various biologically important compounds used in the treatment of various diseases (1) and has a significant place in the pharmaceutical R&D studies (2). Thus the combination of the two ring system into compounds; A and B were attractive, we studied apoptotic effect of these compounds on the human breast cancer MCF-7 cells. The balance between cell proliferation and apoptosis is very important in the formation of cancer. Caspases are the major executioners which lead to apoptotic cell death. Caspases 8 and 9 are the most important members of this group (3). Methods: Pyrrolidine derivatives bearing the indole ring have been synthesized and characterized as indicated our previous studies (4). Three rep...
Synthesis of acylthiourea derivatives and their acid dissociation constants
Efeoglu, Cagla | Karasu, Elize | Nural, Yahya
2025-12-31
Synthesis and antimycobacterial activity of Co(III) complexes of N-benzoyl-4,6-dioxo-hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carbothioamide derivatives”,
Nural, Yahya | Gemili, Muge | Ersen, Duygu | Ulger, Mahmut | Belveren, Samet | Poyraz, Samet | Serin, Mehmet Sami | Dondas, Haci Ali
S) ligands, play an impotrant role in drug research studies and it has been reported that some of Co(III) complexes show antimycobacterial, antimicrobial, antiviral and other biological activities [1]. Likewise, N-aryl/acyl thiourea derivatives have been intensivelly studied in many chemistry disciplines due to their significant complexation and biological properties [2]. One of the other important classes of drug research studies is heterocyclic compounds containing nitrogen atom as pyrrolidine and its derivatives [3].
Synthesis of Bis-Thiourea Derivatives and Their Acid Dissociation Constants
Efeoglu, Cagla | Tiken, Şit | Nural, Yahya
2025-12-31
The Effects of Quercetin on Bone Quality in Healthy and STZ-İnduced Diabetic Rats: A Biomechanical and ICP-MS Study
Nural, Yahya
Type 1 diabetes mellitus (DM), characterized by hyperglycemia and bone loss, have been reported to be related with the increased risk of osteopenia/osteoporosis in humans (1,2). Quercetin, a naturally occurring flavonoid, has protective effects on β-cells in DM, is capable to decrease high blood glucose levels, and has been reported to be have beneficial effects on bone cells (1). Thus, the aim of the present study was to investigate the effects of QE on bone quality in healthy and STZ-induced diabetic rats. For this purpose, fifty-two, Wistar-Albino male rats (4-month; 288–396 g) were assigned randomly into four groups: sham (treated with saline), QE (treated with 50 mg/kg QE), diabetes (DM; received 45 mg/kg i.p. injection of STZ+treated with saline), and diabetes+QE (rec...
