-
Desalination and Water Treatment5
-
Chemosphere2
-
Environmental Research2
-
Fuel2
-
Journal of Environmental Chemical Engineering2
-
Journal of the Iranian Chemical Society2
-
Journal of the Neurological Sciences2
-
Asia Pacific Journal of Innovation and Entrepreneurship1
-
ASIA-PACIFIC JOURNAL OF CHEMICAL ENGINEERING1
-
ASSISTIVE TECHNOLOGY1
Tardive dyskinesia is not associated with the polymorphisms of 5-HT2A receptor gene, serotonin transporter gene and catechol-o-methyltransferase gene
Erdal, Mehmet Emin
Background. – The pathophysiology of tardive dyskinesia (TD) is not completely understood. Aim. – To assess the relationship of TD with 5-HT2A receptor gene, serotonin transporter gene (5 HTT), and catechol-o-methyltransferase (COMT) gene polymorphisms. Method. – Our study comprised 111 unrelated subjects who strictly met DSM-IV criteria for schizophrenia and 32 TD, and 79 healthy unrelated controls; all the subjects were of Turkish origin. The analyses of 5-HT2A receptor gene, 5 HTT gene, and COMT gene polymorphisms were performed using polymerase chain reaction (PCR) technique. Results. – The polymorphisms of these genes were not significantly different between the schizophrenic patients, TD and control subjects. Conclusion. – Our findings indicated that 5-HT2A receptor gene, 5 HTT gene,...
Degradation of chloramphenicol and metronidazole by electro-Fenton process using graphene oxide-Fe3O4 as heterogeneous catalyst
Gözmen Belgin | Görmez Özkan
This study investigates the degradation and mineralization of two widely used antibiotics, chloramphenicol and metronidazole, by an electro-Fenton process using graphene oxide-Fe3O4 as a heterogeneous catalyst. The graphene oxide-Fe3O4 composite was typically characterized through conventional spectroscopic and surface analytical methods. The effects of treatment time, pH, catalyst concentration and applied current were examined. In the absence of the graphene oxide-Fe3O4 catalyst (homogeneous environment), the optimum mineralization rates obtained were 57 and 71% at pH 3 and 300 min treatment time for metronidazole and chloramphenicol solutions, respectively. When the optimum graphene oxide-Fe3O4 concentration of 0.5 g L−1 was used, mineralization rates of 73 and 86% were achieved respect...
Comparative degradation of 5-fluorouracil in aqueous solution by using H2O2-modified subcritical water, photocatalytic oxidation and electro-Fenton processes
Gözmen, Belgin
This study investigated the degradation of the antineoplastic agent 5-fluorouracil (5-FU) widely applied to treat different cancers using different advanced oxidation processes such as electro-Fenton (EF), photocatalysis with TiO2, and H2O2-modified subcritical water oxidation. The treatment with the EF process was the most efficient compared to others. Interestingly, in the EF process, the oxidative degradation of 5-FU behaved differently depending on the anode used. At low currents (20 and 40 mA), Pt and DSA anodes performed better than BDD and Ti4O7 anodes. In contrast, at the higher current of 120 mA, the production of heterogeneous hydroxyl radicals (M(• OH)) became important and contributed significantly to the oxidation of 5-FU in addition to homogeneous • OH generated in th...
Application of the central composite design to mineralization of olive mill wastewater by the electro/FeII/persulfate oxidation method
Gözmen, Belgin | Görmez, Özkan | Yabalak, Erdal
The olive mill wastewater is a major environmental problem, which is waiting for effective treatment. In this study, the mineralization of olive mill wastewater was investigated using the electro/FeII/persulfate process. The central composite design was utilized to examine the effect of each experimental variables (concentration of persulphate and FeII, treatment time and constant current) on the mineralization of olive mill wastewater. The optimum chemical oxygen demand removal percentage was obtained as 71.2% where the reaction conditions were 200 mA current, 250 mM persulphate, 25 mM FeII, and 6 h reaction time. In addition, the maximum percentage of total phenolic removal and the energy consumption were 88% and 4.50 kWh/kgCOD, respectively, which were obtained at the same reaction ...
Synthesis of biomass-based BiOI@Hydrochar heterogeneous catalyst and investigation of its activity in sonocatalytic process
Gözmen, Belgin | Çomak, Gürbüz | Görmez, Özkan
Innovative studies in recent years to remove pollutants discharged into water resources through various means are critically important for protecting existing water resources. An important part of these studies is heterogeneous catalysis-based AOPs, where new generation composite materials are used and high organic pollutant degradation has been achieved. This study used the solvothermal approach to produce a BiOI@BH sonocatalyst doped with hydrochar (BH). A variety of analysis techniques, including XRD, FESEM, EDS, FTIR, DRS, and BET surface analysis, were used to assess changes in the physico-chemical properties of the BiOI@BH structure in comparison to BiOI. Both the adsorption and sonocatalytic degradation processes for the methylene blue aqueous solution were found to be more successf...
Electrocoagulation and nanofiltration integrated process application in purification of bilge water using response surface methodology
Gözmen, Belgin | Dizge, Nadir | Turabik, Meral | Gülsen, H. Elif
Marine pollution has been considered an increasing problem because of the increase in sea transportation day by day. Therefore, a large volume of bilge water which contains petroleum, oil and hydrocarbons in high concentrations is generated from all types of ships. In this study, treatment of bilge water by electrocoagulation/electroflotation and nanofiltration integrated process is investigated as a function of voltage, time, and initial pH with aluminum electrode as both anode and cathode. Moreover, a commercial NF270 flat-sheet membrane was also used for further purification. Box–Behnken design combined with response surface methodology was used to study the response pattern and determine the optimum conditions for maximum chemical oxygen demand (COD) removal and minimum metal ion conte...
Examination of individuals' depression, anxiety, and stress levels during the COVID-19 pandemic in Turkey
Erdoğan, Semra | Can, Ahu Aksoy | Yılmaz, Duygu Vefikuluçay
Purpose: This research was conducted to determine the depression, anxiety, and stress levels of individuals during the COVID-19 epidemic. In addition, the compatibility of the Depression-Anxiety-Stress Scale (DASS-21) scale results with the participants' feeling depressed, anxious, and stressed were examined. Design and methods: The sample of the study consisted of 870 individuals over the age of 18 between May–August 2021. The data of the study were collected online, using the personal information form and DASS-21. Results: In our study, it was observed that 22.3 % of the participants were severely depressed, 19.0 % were highly anxious and 14.3 % were highly stressed. In addition, a relationship was determined between many sociodemographic variables and depression, anxiety, and stress lev...
Investigation of efflux pump genes in isoniazid resistant Mycobacterium tuberculosis isolates
Kaya, Hamide | Ersoy, Leyla | Ülger, Mahmut | Bozok, Taylan | Aslan, Gönül
Background: Tuberculosis (TB) is one of the most important infectious diseases worldwide. Resistance to antituberculosis drugs develops because of genetic mutations that render drug-activating enzymes inactive, changes in cell wall permeability, and increased expression of efflux pump genes and also combination therapy with efflux pump inhibitors may be more effective in drug-resistant TB patients. Aims: To investigate the effect of verapamil (VR) on isonicotinic acid hydrazide (INH) resistance and the expression of 21 efflux pump genes in INH monoresistant MTBC clinical isolates. Study design: In vitro study. Methods: In our mycobacteriology laboratory, 10 INH monoresistant and 10 primary anti-TB drug-susceptible MTBC clinical isolates were selected. Drug susceptibilities for INH and V...
SVM-SMO-SGD: A hybrid-parallel support vector machine algorithm using sequential minimal optimization with stochastic gradient descent
Mutlu, Gizen | Acı, Çiğdem
The Support Vector Machine (SVM) method is one of the popular machine learning algorithms as it gives high accuracy. However, like most machine learning algorithms, the resource consumption of the SVM algorithm in terms of time and memory increases linearly as the dataset grows. In this study, a parallel-hybrid algorithm that combines SVM, Sequential Minimal Optimization (SMO) with Stochastic Gradient Descent (SGD) methods have been proposed to optimize the calculation of the weight costs. The performance of the proposed SVM-SMO-SGD algorithm was compared with classical SMO and Compute Unified Device Architecture (CUDA) based approaches on the well-known datasets (i.e., Diabetes, Healthcare Stroke Prediction, Adults) with 520, 5110, and 32,560 samples, respectively. According to the result...
PPAR-g2 Pro12Ala polymorphism is associated with weight gain in women with gestational diabetes mellitus
Tok, Devrim | Erdal, Mehmet Emin
Objective: The polymorphisms of peroxisome proliferator–activator receptor-g2 (PPAR-g2) have been suggested to affect glucose metabolism and weight gain. Both conditions show great variations during pregnancy that makes pregnancy a suitable condition to detect any metabolic abnormalities related to PPAR-g2 polymorphisms. The objective of this study is to investigate the prevalence and metabolic impacts of PPAR-g2 polymorphism in control pregnant women and in patients with gestational diabetes mellitus (GDM). Methods: In this case-control study, anthropometric and metabolic variables of 100 non-diabetic pregnant women and of 62 women who were diagnosed as having GDM according to 100 g oral glucose tolerance test (OGTT) were compared on the basis of PPAR-g2 polymorphism by univariate analysi...
A Research On Women’s Entrepreneurship Motivation: Sample of Adana Province
Özsungur, Fahri
Women's entrepreneurship is at the forefront of what matters in contemporary issues and incentive policies. Gaining competitive advantage is also important in terms of factors such as women's development, economic growth and social equilibrium. Positive discrimination towards women's entrepreneurship processes plays an important role in raising employment rates. The evaluation of entrepreneurship from a different point of view, reveals the necessity of investigating the factors that affect women's entrepreneurship. In this study, the factors affecting women's entrepreneurship were aimed to examine through comprehensive literature review, and factors affecting and limiting women's entrepreneurship were tried to be determined using Mixed-Method Evaluation Design. In this framework, the reaso...
Association of insulin receptor substrate-1 G972R variant with baseline characteristics of the patients with gestational diabetes mellitus
Tok, Devrim | Erdal, Mehmet Emin
Objective: Insulin receptor substrate-1 (IRS-1) expression and tyrosine phosphorylation is decreased during pregnancy. Pregnancy may be a suitable condition to detect any abnormalities related to IRS-1 polymorphisms. Therefore, we aimed to investigate the prevalence and metabolic impacts of IRS-1 G972R polymorphism in patients with gestational diabetes mellitus (GDM). Study design: Anthropometric and metabolic variables of 62 women who were diagnosed as having GDM according to 100 g oral glucose tolerance test were compared on the basis of IRS-1 polymorphism by univariate analysis of covariance. Results: Patients with IRS-1 G972R were more obese at the beginning of pregnancy, had higher serum fasting insulin and glucose levels. Weight gain during pregnancy and insulin and glucose levels af...
Cytotoxic effect of silica nanoparticles on human retinal pigment epithelial cells
Çömelekoğlu, Ülkü | Kibar, Deniz | Yıldırımcan, Saadet | Yılmaz, Şakir Necat
In recent years, the use of nanotechnology-based methods has become widespread in the treatment of ocular diseases. Silica nanoparticles (SiO2 NPs) are most common used NPs in medical field due to their physicochemical properties. SiO2 NPs can easily cross biological membranes and interact with basic biological structures, causing structural and functional changes in cells. In this study, it was aimed to investigate the dose dependent effect of SiO2 NPs on retinal pigment epithelium (RPE) in vitro using electrobiophysical, biochemical and histological methods. A commercially purchased human RPE (hARPE-19) cell line was used in this study. Cells were divided into four groups as control, 50 mg/mL SiO2, 100 mg/mL SiO2 and 150 mg/mL SiO2 groups. Cell index, apoptotic activity, cell cycle and ...
Adsorption of Malachite Green on Fe-modified biochar: influencing factors and process optimization
Gözmen, Belgin
Paper sludge and wheat husk biochar was converted to a Fe-composite through a simple coprecipitation process and its adsorption behavior was tested against an emerging pollutant, Malachite Green (MG). Response surface methodology was employed to determine the optimum experimental conditions and the interactions between pH, initial MG concentration, temperature and treatment time. The maximum adsorption percentage obtained experimentally was 97.1%, whereas the Box– Behnken design predicted a maximum adsorption of 98%, at pH 6.16, initial MG concentration of 6.56 ppm, temperature of 34.75°C and treatment time of 22 min. Compared with the original biochar, the Fe-modified sample improved the adsorption of MG by ~34%. The adsorption mechanism followed the Langmuir model (qmax = 172.3 mg/...
Valorization of loquat seeds by hydrothermal carbonization for the production of hydrochars and aqueous phases as added-value products
Gözmen, Belgin | Görmez, Özkan | Saçlı, Barış | Çalhan Doğan, Selda
In the framework of circular bio-economy, waste loquat seeds were utilized for the production of two addedvalue products. The seeds were hydrothermally carbonized at a temperature range of 150–250 ◦C and time range 2–6 h and the resultant hydrochars and aqueous phases were characterized using various methods. The optimum higher heating value of 30.64 MJ kg− 1 , ash content of 1.99 wt % and alkali index of 0.05 were achieved for the hydrochar prepared at 250 ◦C and 6 h, establishing its suitability for energy-related applications. The aqueous phase obtained at 250 ◦C and 6 h achieved 90% scavenging of the 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) radical and had a IC50 value of 43.71 μg mL− 1 . Principal component analysis showed that the production of phenols, ketones, alkenes a...
Electrolysis of coal slurries to produce hydrogen gas: Relationship between CO2 and H2 formation
Gözmen, Belgin
The purpose of this study was to produce hydrogen gas by electrolysis of coal slurries and to investigate the relation between hydrogen (H2) and carbon dioxide (CO2) formation. Electrolysis of coal slurries was evaluated at 40 °C and 1.0 V cell potential to examine H2 and CO2relationship. When electrolysis was performed after the coal slurry was mixed with Fe(II)/Fe(III) ions and stirred overnight (>12 h), no CO2 gas was observed at the anode compartment. The results of total organic carbon (TOC) indicated that after electrolysis, few organic compounds were transformed into the solution and these organic compounds did not convert into CO2. GC analysis, on the other hand, revealed that the H2 collected at the cathode was pure and did not require any further purification process. Hydrogen ge...