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Drug and Chemical Toxicology4
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The Pain Clinic4
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Desalination and Water Treatment2
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JOURNAL OF POLITICAL POWER2
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Toxicological & Environmental Chemistry2
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Aquatic Ecosystem Health & Managemen1
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BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT1
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Biotechnology & Biotechnological Equipment1
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Biotechnology & Biotechnological Equipment1
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Cambridge Review of International Affairs1
The Tumor Necrosis Factor-A -308 G/A Polymorphism and the Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Polymorphisms, in Asthmatic Patients and Healthy Subjects
Erdal, Mehmet Emin | Ay, Özlem İzci
Asthma is a chronic inflammatory disorder of the airways in which many cells and cellular elements play a role. Like other atopic diseases, asthma is a complex disorder caused by interactions between multiple genes of small to modest effect and equally important environmental factors. The aim of this study was to determine the TNF-α -308 G/A polymorphism and the TRAIL polymorphisms, and their influence on asthma in asthmatic patients and healthy subjects. The study population consists of 51 asthmatic patients (47 female and 4 male) and 72 healthy subjects (62 female and 10 male). The mean age of the asthmatic patients and healthy controls were 45.33±14.05, and 41.88±17.41 years, respectively. The asthmatic patients and healthy controls were similar with respect to their ages and sex charac...
Significance of catechol-O-methyltransferase gene polymorphism in myofacial pain syndrome
Erdal, Mehmet Emin
The objective was to investigate possible association of the catechol o-methyl transferase (COMT) gene polymorphisms with myofacial pain syndrome (MFPS). The polymorphism of the COMT gene was compared between 49 patients with MFPS and 113 control subjects. Relationship between COMT polymorphism and psychiatric status of the patients was also assessed using SCL-90-R, BDS, and STAI-I and II tests. A PCR-based restriction fragment length polymorphismassay was used to detect G ! A transition at position 1947 in COMT. There was no relationship between MFPS and COMT polymorphism (p > 0:05). The patients who had MFPS without any temporomandibular joint problem had signi cantly higher expression of LL genotype when compared to those with joint problems (p < 0:05). There was no relationship betwee...
Monoamine oxidase-A gene promoter polymorphism in female migraineurs
Erdal, Mehmet Emin
Objective: To assess whether there is a relationship between monoamine oxidase-A (MAOA) gene promoter polymorphism and migraine in female patients. Study design: A polymerase chain reaction based study in which MAOA promoter polymorphism was studied in 54 female migraineurs and 52 controls. Methods: The low (3-repeat) and high (one of 3.5, 4 or 5 repeat units) activityMAOA alleles were detected. The genotypes and allele frequencies were compared both within and between the groups. Results: The representation of both low (1/ 1) and high (2/ 2) activity genotypes were similar between the female migraineurs and controls. The allele frequencies were also similar between these groups. There was no relationship between the presence or absence of aura and MAO polymorphism. Conclusion: MAOA gene p...
Degradation of isoniazid by anodic oxidation and subcritical water oxidation methods: Application of Box–Behnken design
Gözmen, Belgin | Görmez, Özkan | Doğan Çalhan, Selda
Pharmaceutical compounds released into the aquatic environment are known to cause toxic effects on the environment. Isoniazid is widely used in the treatment of tuberculosis and is, therefore, frequently encountered in environmental waters. In this study, the degradation of isoniazid was investigated by anodic oxidation and subcritical water oxidation method which are members of Advanced Oxidation Processes. The Box–Behnken Design was used to determine the effects of current, initial concentration, and electrolysis time on mineralization in the anodic oxidation process, which carried out a cell with a Pt cathode and boron-doped diamond anode. The highest mineralization value of 78.14% was achieved at optimal conditions of 300 mA, 3 h, and 100 mg/L initial concentration. The degradation of ...
Removal of imipramine using advanced oxidation processes: Degradation products and toxicity evolution
Doğan Çalhan, Selda | Görmez, Özkan | Gözmen, Belgin | Şüküroğlu, Ayça
Pharmaceuticals are frequently detected in natural and wastewater bodies, and are very important in environmental toxicology because of their stable nature. Advanced oxidation methods used to remove contaminants are of great benefit, especially removing pharmaceuticals unsuitable for biodegradation. In this study, imipramine was degraded by anodic oxidation and subcritical water oxidation, which are advanced oxidation methods. The determination of degradation products was performed by Q-TOF LC/MS analysis. The genotoxicity and cytotoxicity of the degradation samples were determined by the in vivo Allium Cepa method. Among the anodic oxidation samples, the lowest cytotoxicity was obtained after using 400 mA current, and 420 min of degradation time. No cytotoxic effect was observed in any su...
Role of 2.4 GHz radiofrequency radiation emitted from Wi-Fi on some miRNA and faty acids composition in brain
Erdal, Nurten | Erdal, Mehmet Emin
The purpose of this study is to investigate the effects of 2.4 GHz Wi-Fi exposure, which is continuously used in the internet connection by mobile phones, computers and other wireless equipment, on microRNA and membrane and depot fatty acid composition of brain cells. Sixteen Wistar Albino rats were divided equally into two groups such as sham and exposure. The rats in the experimental group (n = 8) were exposed to 2.4 GHz RFR emitted from a Wi-Fi generator for 24 h/ day for one year. The animals in the control group (n = 8) were kept under the same conditions as the experimental group, but the Wi-Fi generator was turned off. At the end of the study, rats were sacrificed and brains were removed to analyze miRNA expression and membrane and depot fatty acids of brain cells. We analyzed the s...
Effects of electromagnetic radiation on neurogenesis and gene expression in amniocytes
Erdal, Nurten | Ay, Özlem İzci | Yıldırım, Didem Derici | Durukan, Hüseyin | Erdal, Mehmet Emin
The aim of the study was to investigate the genetic effects of commonly used radiofrequency on the amniocytes of pregnant women by examining the changes in the expression of genes related to signal transduction and neurogenesis induced by electromagnetic fields of radiofrequencies of 1800 and 2100 MHz by real-time PCR. Upon exposure of the amniocytes to electromagnetic radiation of 2100 MHz at high field strength, the expression levels of genes with important functions in the Wnt signaling pathways as well as neurogenesis-related genes were increased. The findings suggest that radiofrequency at high field strengths can have genotoxic effects during pregnancy.
Not only Relational but also Structural: Revisiting there solution of the 1998 October crisis through elements of structural power
Sarı, Buğra
The 1998 October Crisis between Turkey and Syria has long beenstudied in various aspects. However, these studies are limited to anunderstanding that depicts the crisis as a relational power relation-ship in which Turkey forced Syria to cease its support for the PKK,which Syria would not have done otherwise. While not rejecting therelational explanation, this paper attempts to complement it witha structural approach, drawing on the post-positivist structuralpower conceptualization, by investigating how Syria’s structurallyshaped subjective interests in the post-Cold War international struc-ture and norms regarding international terrorism disempowered it resisting Turkey’s demands.
Development and Validation of Breastfeeding Expectations Scale-A (BES-A): A Questionnaire for Pregnant Women
Eker, Aslı | İsbir, Gözde Gökçe
The aim of this work was to develop a measurement for the expectations of pregnant women about breastfeeding and examine the psychometric properties of the scale. The study was conducted with two separate samples, including women who were �28 weeks pregnant. The first sample, comprising 322 women aged 19 to 49 years (M ¼ 28.19; SD ¼ 4.86), was formed to conduct an exploratory factor analysis (EFA). The second sample, which consisted of 274 women aged 18 to 42 years (M ¼ 28.16; SD ¼ 4.85), was formed to conduct a confirmatory factor analysis (CFA). The Prenatal Attachment Inventory and the Depression Anxiety Stress Scale were administered. Data were collected between April and November 2021. In the EFA, two factors were obtained: "1: Enthusiastic Expectations of Breastfeeding" and "2: F...
Dream vacations of children: exploring key motivations and preferred experiences by drawing
ÖZKAN BUZLU, Mehtap
Children have an important place in the family travel market as they have a strong influence on holiday decisions and their satisfaction can directly affect their parents’ satisfaction and future behavioural intentions. To attract this market and provide child tourists with a satisfying holiday experience, it is important to better understand their motivations and preferences. The aim of this research is to identify children’s motivations and preferred destinations and activities in family tourism context. In this qualitative study, where children’s voices were taken into account by giving them the opportunity to express their dream family holiday experience ‘drawing’, one of the widely preferred child-friendly techniques to reveal children’s perspectives, was used. A total of 103 literate...
Monoamine oxidase-A gene promoter polymorphism in temporomandibular joint pain and dysfunction
Erdal, Mehmet Emin | Erdal, Nurten
Objective: In this study we aimed to evaluate the relationship between temporomandibular joint pain and dysfunction (TMJPD) within the frame of monoamine oxidase-A gene (MAO-LPR) gene polymorphism. Methods: Ninety-three patients with TMJPD, and 91 healthy volunteers were included in the study. Symptom Checklist-90-Revised (SCL-90-R), Montgomery-Asberg Depression Rating Scale (MADRS), and State and Trait Anxiety Inventory tests (STAI-I and STAI-II) were applied to the patients that were diagnosed as having TMJPD according to the standard clinical examination protocol. Blood samples were taken from the patients, and the variability in the MAO-A gene was analyzed by amplification of DNA with polymerase chain reaction (PCR) for a genetic association study. Results: The analysis of allele and g...
Not only Relational but also Structural: Revisiting the Resolution of the 1998 October Crisis through Elements of Structural Power
Sarı, Buğra
The 1998 October Crisis between Turkey and Syria has long been studied in various aspects. However, these studies are limited to an understanding that depicts the crisis as a relational power relationship in which Turkey forced Syria to cease its support for the PKK, which Syria would not have done otherwise. While not rejecting the relational explanation, this paper attempts to complement it with a structural approach, drawing on the post-positivist structural power conceptualization, by investigating how Syria’s structurally shaped subjective interests in the post-Cold War international structure and norms regarding international terrorism disempowered it resisting Turkey’s demands.
The 1438G/A polymorphism of the 5-HT2A receptor gene is associated with aura in migraine
Erdal, Mehmet Emin
Objective: To nd out the role of the 1438G/A polymorphismof the 5-HT2A promoter region in migraine. Study design: A polymerase chain reaction (PCR) analysis of the 1438G/A polymorphism was performed in 61 migraineurs and 57 healthy controls. Methods: The results of 1438G/A polymorphism were compared between the migraineurs and controls as well as between migraineurs with aura (MA) and those without aura (MOA). Results: The 1438 G/A polymorphism of 5-HT2A receptor gene was similar in both migraineurs and controls .p D 0:6/. There was a signi cant relationshipbetween the presence of G/G genotype and MA .p D 0:02/ while A/A and A/G genotypes were similar in both MA and MOA .p > 0:05/. Conclusion: The 1438G/A polymorphism of the 5-HT2A receptor gene is not associated with increased risk of ...
The steppe and the stone: the international relations worldview in the Orkhon Inscriptions
Sarı, Buğra
This study examines the international relations worldview articulated in the Orkhon Inscriptions—8th-century stone monuments erected by the Türk Khaghanate in Central Asia. Far from being mere commemorative texts, the inscriptions present a complex political philosophy grounded in divine sanction, nomadic statecraft, and strategic realism. Drawing on scholarly translations of the Old Turkic text, the analysis interprets the inscriptions strictly on their own terms and situates them within the broader field of International Relations (IR) theory. Through comparative engagement with Realism, Liberalism and Constructivism, the study reveals both convergences and disjunctions between Turkic thought and mainstream IR paradigms. The inscriptions depict a worldview that is Realist in its emphasis...
Correlates of Posttraumatic Stress Disorder in the Aftermath of the February 2023 Earthquake in Turkey
Alpay, Emre Han
On February 6, 2023, an earthquake registering 7.8 on the Richter scale struck southeast Turkey, and this was followed by a second earthquake of magnitude 7.5. The earthquake resulted in widespread loss, devastation, and destruction and is anticipated to bear a significant psychological toll on survivors. This study aimed to investigate the prevalence and correlates of ICD-11 posttraumatic stress disorder (PTSD) in those living in earthquake-affected areas of Turkey. The sample was a convenience sample of 527 adults living in earthquake-affected areas of Turkey. Prevalence rates and gender differences in exposure to earthquake-related traumatic events were investigated. Moreover, prevalence rates of ICD-11 PTSD were computed, and demographic and trauma-related correlates of ICD-11 PTSD wer...
Effects of peritraumatic reactions on post-traumatic stress among Kahramanmaras earthquake survivors
Alpay,, :Emre Han | Acı, Arzu Aydın
Purpose: Peritraumatic reactions play a crucial role in the development of mental health problems, including depression and post-traumatic stress disorder. Therefore, this study sought to examine the influence of the peritraumatic reactions, including peritraumatic dissociation, peritraumatic distress, mental defeat, and tonic immobility, on post-traumatic stress disorder and major depressive disorder in earthquake survivors. Materials and methods: A total of 261 adult participants aged between 18 and 65 (Mage=29.20, SD = 28.06, 162 were female, and 99 were male) who were exposed to the Kahramanmaras earthquake in February 2023 were recruited in the study. Data were collected between April 10 and 18, 2023, two months after the earthquake. Participants completed questionnaires, including Th...