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Fakülteler11
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Tıp Fakültesi11
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Cerrahi Tıp Bilimleri Bölümü11
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Kadın Hastalıkları ve Doğum Anabilim Dalı11
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Temel Tıp Bilimleri Bölümü9
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Tıbbi Biyoloji ve Genetik Anabilim Dalı9
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Biyoistatistik ve Tıbbi Bilişim Anabilim Dalı4
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Biyofizik Anabilim Dalı3
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İnsan ve Toplum Bilimleri Fakültesi2
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Arap Dili ve Edebiyatı Bölümü2
PPAR-g2 Pro12Ala polymorphism is associated with weight gain in women with gestational diabetes mellitus
Tok, Devrim | Erdal, Mehmet Emin
Objective: The polymorphisms of peroxisome proliferator–activator receptor-g2 (PPAR-g2) have been suggested to affect glucose metabolism and weight gain. Both conditions show great variations during pregnancy that makes pregnancy a suitable condition to detect any metabolic abnormalities related to PPAR-g2 polymorphisms. The objective of this study is to investigate the prevalence and metabolic impacts of PPAR-g2 polymorphism in control pregnant women and in patients with gestational diabetes mellitus (GDM). Methods: In this case-control study, anthropometric and metabolic variables of 100 non-diabetic pregnant women and of 62 women who were diagnosed as having GDM according to 100 g oral glucose tolerance test (OGTT) were compared on the basis of PPAR-g2 polymorphism by univariate analysi...
Association of insulin receptor substrate-1 G972R variant with baseline characteristics of the patients with gestational diabetes mellitus
Tok, Devrim | Erdal, Mehmet Emin
Objective: Insulin receptor substrate-1 (IRS-1) expression and tyrosine phosphorylation is decreased during pregnancy. Pregnancy may be a suitable condition to detect any abnormalities related to IRS-1 polymorphisms. Therefore, we aimed to investigate the prevalence and metabolic impacts of IRS-1 G972R polymorphism in patients with gestational diabetes mellitus (GDM). Study design: Anthropometric and metabolic variables of 62 women who were diagnosed as having GDM according to 100 g oral glucose tolerance test were compared on the basis of IRS-1 polymorphism by univariate analysis of covariance. Results: Patients with IRS-1 G972R were more obese at the beginning of pregnancy, had higher serum fasting insulin and glucose levels. Weight gain during pregnancy and insulin and glucose levels af...
Gebe kadınlarda cinsel fonksiyon bozukluklarının araştırılması
Bektaş, Kıvılcım.
ÖZET Bu çalışma, Mersin Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim dalında, etik kurulundan onay alınarak yapılmış prospektif kesitsel bir araştırmadır. Çalışmada gebelikte cinsel fonksiyon bozukluklarının değerlendirilmesi amaçlanmıştır. Bu bağlamda riskli gebeler (gebeliği sırasında diabet, hipertansiyon, tiroid fonksiyon bozukluğu gibi hastalıkları bulunan), sağlıklı gebeler (gebelik öncesinde veya gebeliği sırasında herhangi bir hastalık saptanmayan) ve reprodüktif (doğurgan) yaşta, sağlıklı ve gebe olmayan kadınların cinsel fonksiyon skorları ve depresyon skorları birbirleriyle karşılaştırılmıştır. Bu çalışmanın gebe evrenini 11 Şubat–11 Eylül 2018 tarihleri arasında Mersin Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum perinatoloji bölümüne başvuran gebel...
Effects of electromagnetic radiation on neurogenesis and gene expression in amniocytes
Erdal, Nurten | Ay, Özlem İzci | Yıldırım, Didem Derici | Durukan, Hüseyin | Erdal, Mehmet Emin
The aim of the study was to investigate the genetic effects of commonly used radiofrequency on the amniocytes of pregnant women by examining the changes in the expression of genes related to signal transduction and neurogenesis induced by electromagnetic fields of radiofrequencies of 1800 and 2100 MHz by real-time PCR. Upon exposure of the amniocytes to electromagnetic radiation of 2100 MHz at high field strength, the expression levels of genes with important functions in the Wnt signaling pathways as well as neurogenesis-related genes were increased. The findings suggest that radiofrequency at high field strengths can have genotoxic effects during pregnancy.
Epitelyal over kanserinde hematolojik parametrelerin klinikopatolojik parametreler, yaşam süresi ve platin direnci ile ilişkisi
Kırat, Samet.
ÖZET Her kanser tipi, kanser veya host hücrelerinden salgılanan sitokinler sayesinde az veya çok oranda inflamatuar belirteçlerin ortaya çıkmasına neden olur. Beyaz küre ve nötrofil sayımı, trombosit sayımı ile C-reaktif protein ve albümin düzeyi ölçümleri; solid kanser tiplerinde en çok çalışılan inflamatuar belirteçlerdendir. Epitelyal over kanserlerinde absolut nötrofil sayısı, trombosit veya lenfosit sayılarında artış olduğu; nötrofil/lenfosit ve trombosit/lenfosit oranlarında değişiklikler olduğu bildirilmiştir. Hatta bazı çalışmalarda bu belirteçlerin prognozla ilişkili olabileceği de iddia edilmiştir. Biz bu çalışmada, bahsi geçen ve tam kan sayımından elde edebileceğimiz bu sistemik inflamatuar yanıt belirteçlerinin epitelyal over kanserinde klinikopatolojik belirteçler ile, tam ve...
Evaluation of glucose metabolism and reproductive hormones in polycystic ovary syndrome on the basis of peroxisome proliferator-activated receptor (PPAR)-g2 Pro12Ala genotype
Tok, Devrim | Erdal, Mehmet Emin
BACKGROUND: Peroxisome proliferator-activated receptor (PPAR)-g2 Pro12Ala polymorphism has been suggested as a protective factor for polycystic ovary syndrome (PCOS). In this study, we aimed to investigate metabolic features and reproductive hormones in women with PCOS and compare these features with control women on the basis of Pro12Ala genotype. METHODS: This study involved 60 randomly selected women with PCOS and 60 controls. Main outcome measures were anthropometric measures, variables of glucose metabolism and reproductive hormones. All the patients were genotyped for Pro12Ala variant of PPAR-g2 gene. RESULTS: Patients with Pro12Ala polymorphism were more obese in both groups. Furthermore, they had lower fasting insulin levels, were less insulin-resistant and were less glucose-intole...
The importance of IRS-1 Gly972Arg polymorphism in evaluating the response to metformin treatment in polycystic ovary syndrome
Tok, Devrim | Erdal, Mehmet Emin
BACKGROUND: Recent evidence suggests that one of the modes of action of metformin may be through phosphorylation of the insulin receptor and insulin receptor substrates. With this in mind, we supposed that the G972A variant of insulin receptor substrate-1 (IRS-1) may modulate the response to metformin treatment in women with polycystic ovary syndrome (PCOS). METHODS: This preliminary study involved 60 randomly selected women with PCOS. All patients received dietary instructions and metformin 500mg three times daily for 6 months. Main outcome measures were androgen levels, parameters of glucose and insulin metabolism and anthropometric variables. After a second evaluation of the patients at 6 months, they were genotyped for the Gly972Arg variant of the IRS-1 gene. RESULTS: Metformin had dif...
Association of Gly972Arg variant of insulin receptor substrate-1 with metabolic features in women with polycystic ovary syndrome
Tok, Devrim | Erdal, Mehmet Emin
Objective: To examine the prevalence and the effects of Gly972Arg (G972A) variant of insulin receptor substrate-1 (IRS-1) in women with polycystic ovary syndrome (PCOS). Design: Controlled clinical study. Setting: An academic clinical research center. Patient(s): Sixty women with PCOS and 60 control women matched for age. Intervention(s): Biometric measures, metabolic and hormonal measures, genetic analyses. Main Outcome Measure(s): Serum androgens, glucose, and insulin were measured. Blood leukocytes were used for genetic analyses. Result(s): The G972A variant was encountered more often in women with PCOS. The G972A carriers were more obese than their counterparts, had higher fasting insulin levels, and were more insulin-resistant. However, androgen levels did not differ on the basis of I...
Yemler Bilgisi Yem Teknolojisi ve Balık Besleme
Bilgüven, Murat
Her havuz alanında ya da yetiştirme biriminden elde edilen balık ve dolayısıyla balık yetiştiriciliğinin kârlılığı, büyük ölçüde kullanılan yemin miktarına bağlıdır. Su ürünleri sistemi ne kadar yoğun olursa yemlemenin önemi o kadar fazla olur ve toplam üretim maliyetinde yem maliyetinin payı da o kadar artar. Bilindiği üzere alabalık başta olmak üzere bazı balıkların yetiştiriciliği için akarsu sistemli tesisler kullanılmakta yada sıcaklığın, su bileşiminin ve akıntının dolayısıyla oksijen yoğunluğunun daha iyi olduğu tatlı su ve kıyılarda ise yüzer ağ kafeslerde yetiştiricilik yapılmaktadır. Su ürünleri yetiştiriciliğinin ileri durumda olduğu ülkelerde entansif yetiştiricilik uygulanmakta ve yetiştirme alanlarında birim hacimde maksimum ürün yetiştirilmeye çalışılmaktadır. Bu tür yetişti...
Role of antioxidant defense system and biochemical adaptation on stress tolerance of high mountain and steppe plants
Keleş, Yüksel
Eleven species were collected from Northwest Anatolian mountains (1500–2000 m) and 18 species were collected from the Central Anatolian steppes (850–1000 m) in June 1998 and 1999. In all the species investigated, the water and dry matter percentages and solute contents were measured. The chlorophyll, b-carotene, ascorbate and a-tocopherol contents and catalase (CAT), superoxide dismutase (SOD) andglutathione reductase (GR)enzymeactivities oftheplants werealsodetermined.Thesteppeplantshadlowerwatercontentcomparedwith alpine plants. The chlorophyll contents of the plants investigated did not change with altitude. However, the carotenoid/chlorophyll ratio of alpine plants was found to be significantly higher. The antioxidant/chlorophyll ratio of the trees and shrubs was higher than that of he...
Effects of electromagnetic radiation on neurogenesis and gene expression in amniocytes,
Erdal, Nurten | Ay, Özlem İzci | Yıldırım, Didem Derici | Durukan, Hüseyin | Erdal, Mehmet Emin
The aim of the study was to investigate the genetic effects of commonly used radiofrequency on the amniocytes of pregnant women by examining the changes in the expression of genes related to signal transduction and neurogenesis induced by electromagnetic fields of radiofrequencies of 1800 and 2100 MHz by real-time PCR. Upon exposure of the amniocytes to electromagnetic radiation of 2100 MHz at high field strength, the expression levels of genes with important functions in the Wnt signaling pathways as well as neurogenesis-related genes were increased. The findings suggest that radiofrequency at high field strengths can have genotoxic effects during pregnancy.