The effects of interleukin (IL)1, 6, 10 and tumor necrosis factor (TNF) gene polymorphisms on CRP levels in coronary artery disease

Ünal, Zeynep Nil | Yaroğlu, Hatice Yıldırım | Yılmaz, Dilek Çiçek | Tamer, Lülüfer

Atherosclerosis is a dynamic and progressing inflammatory pathology. Studies have demonstrated that genetic variants that directly or indirectly alter the inflammatory system raise the risk of coronary artery disease (CAD). Genetic variations account for the variances in how the disease develops and progresses as well as the disclosure of poor prognostic information linked to extreme inflammatory reactions in individuals. In our investigation, we aimed to determine whether there may be a connection between CAD and the IL-1 C-889T, IL-6 G-174C, IL-10 G-1082A, and TNF G-308A polymorphisms. In the study, 80 patients with coronary artery stenosis of 70% or more and 80 people with normal coronary arteries were both evaluated using coronary angiography. An enzymatic colorimetric approach was use...

The relationship between ghrelin and ghrelin leu72met polymorphism in coronary artery disease

Purpose: Ghrelin represents a hormone, which is defined as an endogenous ligand bound to the growth hormone-releasing hormone receptor (GHS-R1a). However, the mechanisms that underlie ghrelin’s impacts on cardiovascular diseases have not been completely detected. For this reason, we aimed to research the relationship between serum ghrelin and ghrelin gene polymorphism in coronary artery disease (CAD). Materials and Methods: The study group consisted of 88 patients diagnosed with a minimum of one coronary artery stenosis over 70%, and the control group comprised 81 individuals without coronary artery lesions. An autoanalyzer was used to analyze fasting blood glucose (FBG) and lipid parameter levels. Ghrelin levels were examined with an enzyme-linked immunosorbent assay (ELISA) kit. Results:...