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Fakülteler6
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Tıp Fakültesi3
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Temel Tıp Bilimleri Bölümü3
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Eczacılık Meslek Bilimleri Bölümü2
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Farmakognozi Anabilim Dalı2
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Eczacılık Fakültesi2
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Ruh Sağlığı ve Hastalıkları Hemşireliği Anabilim Dalı1
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Hemşirelik Fakültesi1
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Histoloji ve Embriyoloji Anabilim Dalı1
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Tıbbi Biyoloji ve Genetik Anabilim Dalı1
Biochemical, Histopathologic, and Genotoxic Effects of Ethanol Extract of Salvia hypargeia (Fisch. & Mey.) on Incisional and Excisional Wounded Diabetic Rats
Guzel, Sevda | Uzun, Cosar | Celik, Ayla | Camlıca, Yusuf | Guler, Gizem | Erdal, Nurten | Tasdelen Bahar | Celikcan, Havva Didem
Purpose: Nonhealing wounds are a serious problem of diabetic patients. Salvia species are traditionally used for the treatment of wounds. The aim of the study was to investigate the effects of ointment prepared with ethanol extract obtained from the aerial parts of Salvia hypargeia, an endemic plant from Turkey, on diabetic rat incisional and excisional skin wounds. Materials and Methods: Male Wistar albino rats (n: 60) were divided into five groups. Diabetes was induced and two concentrations (0.5% and 1%) of the extract were used for ointments and applied on wounds for 7 and 14 days. Fito cream was chosen as a reference drug. Results: In excisional wounds, healing ratios of 0.5% (63.4% and 99.3%) and 1% (65.5% and 99.9%) S. hypargeia groups were higher compared to control (35.9% and 75.1...
Microribonucleic acid dysregulations in children and adolescents with obsessive–compulsive disorder
MEHMET EMİN ERDAL | ÖZLEM İZCİ AY | MUSTAFA ERTAN AY | BAHAR TAŞDELEN
Aim: Obsessive–compulsive disorder (OCD) is a disorder characterized by the presence of obsessions and/or compulsions. Although disorder etiology and pathogenesis remains unknown, several theories about OCD development have been proposed, and many researchers believe that it is caused by both genetic and environmental factors. In the current study, our aim was to investigate miRNA levels in OCD. Methods: In the current study, we evaluated miR18a-5p, miR22-3p, miR24-3p, miR106b-5p, miR107, miR125b-5p, and miR155a-5p levels in child and adolescent OCD patients. The research sample consisted of a group of 23 OCD patients and 40 healthy volunteer controls. Results: There was no significant difference in age and sex between the two groups (P0.05).The levels of miR22-3p, miR24-3p, miR106b-5p, m...
Effect of axitinib on inflammation in experimental corneal neovascularization model in rats
Canacankatan, Necmiye | Dinç, Erdem | Kibar, Deniz | Antmen, Ş. Efsun | Yılmaz, Banu COŞKUN | Taşdelen, Bahar
Purpose: This study investigated the antiinflammatory efficacy of topical application of a selective tyrosine kinase receptor inhibitor (TKI), Axitinib in experimental corneal neovascularization (CNV) model in rats. Vascular endothelial growth factor receptor 1 (VEGFR1), VEGFR2 and VEGFR3 were evaluated as angiogenic markers, nuclear factor kappa B (NF-κB), tumor necrosis factor α (TNFα) and cyclooxygenase-2 (COX2) were determined as inflammatory markers and also histopathological evaluations were carried out. Materials and Methods: Experimental CNV model was established by silver nitrate cauterization in right eye. 6 groups were included as Control; CNV; CNV+DMSO; CNV+0.04% Axitinib; CNV+0.08% Axitinib and CNV+0.24% Axitinib. The corneas were collected and VEGFR1, VEGFR2, VEGFR3, NF-κB...
Nursing students' attitudes to suicide and suicidal persons: A cross‐national and cultural comparison between Turkey and the United Kingdom
Yılmaz, Mualla | Taşdelen, Bahar
Introduction: Suicide is a major public health issue internationally, and the impact of positive or negative attitudes amongst the mental health professional workforce warrants scrutiny. The study aimed to examine English and Turkish nursing students’ attitudes towards people with suicidal behaviour. Method: This cross-cultural study reports on attitudes of 240 nursing students towards suicide in Turkey and 82 nursing students in the UK. A reliable and valid 24 item “Attitudes towards Suicide Scale” and “Social Reactions to Suicidal Persons Scale” were used to measure attitudes. Results: The UK nursing students were found to display more accepting attitudes to suicide, and scored higher on acceptability of suicide, seeing suicide as a solution and open reporting and discussion of suicide s...
Wound healing activity of Salvia huberi ethanolic extract in streptozocin-induced diabetic rats
Guzel Kara, Sevda | Uzun, Cosar | Celik , Ayla | Camlica, Yusuf | Guler ,Gizem | Erdal , Nurten | Tasdelen, Bahar
Objective: The aim of this study was to examine the in vivo wound healing potential of Salvia huberi Hedge (endemic to Turkey) on excision and incision wound models in diabetic rats. Method: Male Wistar albino rats, 3-4 months old and weighing 180-240g were used. The animals were randomly divided into five groups including Control, Vehicle and Fito reference, and two different concentrations (0.5% and 1% weight/weight (w/w)) of ethanol extract of Salvia huberi were investigated in both wound models on streptozocin-induced diabetic rats using macroscopic, biomechanical, biochemical, histopathological, genotoxic and gene expression methods over both seven and 14 days. Fito cream (Tripharma Drug Industry and Trade Inc., Turkey) was used as the reference drug. Results: A total of 60 rats were ...
Investigation of the relationship between periodontal and systemic inflammation in children with Sickle Cell Disease: A case- control study
Öztürk, Candan | Aslan Tek, Sebahat | Taşdelen, Bahar | Ünal, Selma
Periodontal diseases are chronic inflammatory diseases and tissue destruction increases with oxidative stress in periodontal tissues. Periodontal diseases are associated with systemic diseases such as diabetes, cardio-vascular diseases and rheumatoid arthritis by means of systemic inflammation. Sickle cell disease (SCD) is a chronic inflammatory disease in which vaso-occlusive crisis and endothelial dysfunction are present. It is not known whether the chronic systemic inflammation seen in SCD affect periodontal tissues. The aim of this study was to investigate the relationship between periodontal and systemic inflammation in children with SCD. Forty-three children with SCD and 43 healthy children were included in the study. Physical, dental and periodontal statuses were examined, blood and...