HIV Enfeksiyonuna Multidisipliner Yaklaşım
ŞAHİNOĞLU, MUSTAFA SERHAT
HIV ile yaşayan bireylerde yaşam süresinin uzamasıyla birlikte geriatrik sorunlar giderek daha belirgin hale gelmiştir. Bu hasta grubunda çoklu komorbiditeler, polifarmasi, frajilite, bilişsel bozukluklar ve fonksiyonel kayıp genel popülasyona kıyasla daha erken yaşlarda ortaya çıkabilmektedir. Kronik inflamasyon, immün yaşlanma ve uzun süreli antiretroviral tedaviler bu süreci etkileyen temel faktörlerdir. Bu nedenle HIV pozitif yaşlı bireylerin izleminde bütüncül ve multidisipliner bir geriatrik yaklaşım büyük önem taşımaktadır.
Bloodstream infections caused by carbapenemresistant Klebsiella pneumoniae: analysis of risk factors, treatment responses and mortality
Bozok, Tuğçe Şimşek | Bozok, Taylan | Şahinoğlu, Mustafa Serhat | Kaya, Hamide | Horasan, Şahin Elif | Kaya, Ali
Objective: Bloodstream infections (BSIs) caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) are a serious threat to public health. In this study, it was aimed to evaluate the risk factors, treatment, length of hospitalisation and mortality of patients with BSI caused by CRKP. Methods: Between October 2021 and October 2023, patients aged 18 years and older who were treated for BSI at Mersin University Faculty of Medicine Hospital and had pathogens identified as CRKP or carbapenem-sensitive Klebsiella pneumoniae (CSKP) were retrospectively reviewed and included in the study. Results: Of the 107 patients with BSI included in the study, 66 (61.7%) had CRKP and 41 (38.3%) had CSKP. The risk factors associated with CRKP in BSIs were found to be acute renal failure (p¼0.048), mech...