Objective: It was aimed to determine the effect of information regarding hysterectomy and the training to cope with anxiety over their anxiety levels, which were given to women before they undergo hysterectomy. Methods: The parallel group post-test randomized controlled experimental design was used. The trial registration for the research protocol was obtained retrospectively from clinicaltrials.gov (NCT05436691) and the protocol was following the non-pharmacological intervention guidelines (CONSORT). The sample of the study consisted of 59 (intervention=30; control=29) women hospitalized in the Gynecology Oncology Clinic of a city hospital in the Eastern Mediterranean Region of Turkey, who were scheduled to undergo hysterectomy between July 15, and December 15, 2018. The women in the experimental group were given information and a training about hysterectomy and coping with anxiety, and furthermore, a training booklet was distributed. Chi-square test, the Independent Sample t test, One Way ANOVA, Scheffe post hoc test, the Binary Logistic Regression analysis and the Hosmer-Lemeshow test were used in the analysis of the data. Results: It was determined that the training did not lead to a statistically significant difference in their anxiety levels but the mean scores obtained from the trait anxiety inventory by the women who received information from the nurse were lower. While the variable “having high school or higher education” increased their situation anxiety levels 1.2 times, the variable “having an income equal to or more than expenses” decreased their anxiety levels 0.8 times (p<0.05). While the variable “having a high school or higher education” increased their trait anxiety level 1.1 times, the variable “having an income equal to or more than expenses” decreased their anxiety levels 0.9 times (p<0.05). Conclusion: While the information and anxiety management training given to women before they undergo hysterectomy are integrated into routine nursing care, the training should be started as soon as hospitalized, and attention should be given to individual and cultural differences.