Issos-Epiphanenia, one of the significant ancient cities of Cilicia Pedias, was urbanized since the Hellenistic period and came under its rule the Byzantine domination (395-635) after the Roman Empire (BC 67). Epiphaneia met with Islamic religion and civilization in the first half quarter of the 7th centenary, in parallel with the Islamization process of Anatolia. Although it was captured by Byzantium again in 965, it was conquered by the Umayyads in the 8th century and then by the Abbasids from the half of the 8th century. The Abbasids used Epiphaneia and its surroundings as a base in the Byzantine expeditions into Anatolia, conquering the coastal cities of the Eastern Mediterranean and by establishing permanent settlements and garrisons. The subject of this article is consists a Group of Abbasid Coins Unearthed in the Ancient City of Erzin-Issos (Epiphaneia). The coins that are the subject of the article are kept in the warehouse section of Hatay Archeology Museum and are considered inventory coins.The purpose of the study is in the light of the coins found in the ancient city; Abbasids, who ruled in Epiphaneia during the Middle Ages; to examine its political, socio-cultural and economic situation. The further increases the importance of this, the lack of sufficient research on the coins of the Abbasid period in the Cilicia Region. As well as coins are unique in their field, they were introduced to the scientific world for the first time in this study. In the content, were examined 5 unique Abbasid period coins found in the rescue excavations between 2006-2016 in the ancient city of Erzin-Issos (Epiphaneia). Lost of all, in the light of existing coins, it is observed that the Abbasids ruled in Epiphaneia from the end of the eighth century to the middle of the tenth century. With coins; Abbasids in the region; It has been reached comments on political, military, socio-cultural, economic and artistic style.