The effects of cadmium on sera glucose and cortisol levels of Clarias gariepinus was studied after exposing the animals to 0.25, 0.50 and 1.00 ppm Cd over 30 days. An autoanalyser was used in determining sera parameters. Sera glucose levels showed no significant difference between the control and 0.25 and 0.50 ppm Cd exposed fish whereas 1.00 ppm cadmium decreased sera glucose significantly (p<0.05). An inverse relationship was found in sera cortisol levels which showed significant increase at 0.25 and 0.50 ppm Cd compared with the control fish (p<0.05).