Tetracyclines are well known for their diverse applications, including the treatment of various infections, the promotion of growth in poultry and cattle, and their use in animal husbandry. However, extended exposure to these antibiotics can lead to health problems and environmental pollution. This necessitates the development of time-saving and environmentally friendly devices, such as chemosensors, for their effective detection. This review provides a detailed account of the applications of the chemosensors as detection tools for tetracyclines, where metal-organic frameworks, metal coordination polymers and nanomaterials are considered as the main categories of these probes. The review highlights current research on the topic, shedding light on different types of chemosensors and their mechanisms of interaction with tetracyclines. Real-sample applications, test-strip determinations and smartphone-assisted detection methods are also briefly discussed. The review also draws attention to some of the areas where research is required. As the review presents the current state of progress in the detection of tetracyclines using chemosensors, it is hoped that it can be used as a stepping stone for future research.