Objectives: The objective of this investigation was to assess the efficacy of XP-Endo Finisher (XPF), XP-Endo Finisher R (XPF-R), passive ultrasonic irrigation (PUI), and conventional needle irrigation (CNI) systems in the removal of AH Plus Bioceramic Sealer from artificial internal root resorption (IRR) cavities. Materials and Methods: A total of 52 mandibular premolars with single oval canals were chosen. Following instrumentation, each tooth was longitudinally sectioned, and an artificial resorption cavity was established at a distance of 8 mm from the apex, with a diameter of 1.6 mm and a depth of 0.8 mm. The root halves were subsequently reassembled after the cavities were filled with sealer (AH Plus Bioceramic sealer). The activation techniques were applied to randomly assign the specimens to four groups (n = 13). The residual sealer was evaluated using a four-point scoring system at 20X magnification. Results: The sealer was not completely removed from the artificial resorption cavities by any of the methods. A statistically significant difference was observed among the groups based on data analysis (p < 0.001). PUI, XPF-R, and XPF demonstrated significantly greater efficacy in sealer removal than CNI (p < 0.05), with no statistically significant differences between XPF, XPF-R, and PUI. The XPF-R system exhibited a higher percentage of &#039;Score 0&#039; outcomes than XPF and PUI, despite no significant statistical differences. Conclusions: XPF, XPF-R and PUI removed more sealer from artificial IRR cavities compared with CNI. These findings indicated that especially XPF-R is an effective additional activation system in IRR cavities filled with bioceramic sealers.