Synthesis of γ,δ-Aziridino α-Amino Acid Derivatives and their Stereoselective Ring Transformation to 2-(Aminomethyl)-1-aminocyclopropanecarboxylic Acid Derivatives

Nural, Yahya

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Yazarlar	Nural, Yahya
Kurum Dışı Yazarlar	De Brabandere, Stijn Mangelinckx, Sven Kadam, Santosh T. Augustyns, Koen Van der Veken, Pieter Tornroos, Karl W. De Kimpe, Norbert
Tek Biçim Adres (URI)	https://hdl.handle.net/20.500.14114/8688
Yayın Türü	Makale
Yayın Yılı	2014
DOI Adresi	10.1002/ejoc.201301030
Yayıncı	WILEY-V C H VERLAG GMBH
Dergi Adı	EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Konu Başlıkları	α-Amino Acid 2-(Aminomethyl)-1-aminocyclopropanecarboxylic Acid Derivatives
İndekslenen Platformlar	Web of Science

1-Benzyl-2-(bromomethyl)aziridine was successfully substituted with protected glycine esters to afford alkyl 3-(N-benzylaziridin-2-yl)-2-aminopropanoates, as constrained heterocyclic diamino acid derivatives, in good isolated yields. These new aziridines proved to be excellent building blocks for ring transformation to the corresponding stereochemically defined 2-(aminomethyl)-1-aminocyclopropanecarboxylic acid derivatives, including methyl esters, piperidyl amides, and free carboxylic acids.

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Eczacılık Fakültesi
Temel Eczacılık Bilimleri Bölümü
Analitik Kimya Anabilim Dalı

Eser Adı dc.title	Synthesis of γ,δ-Aziridino α-Amino Acid Derivatives and their Stereoselective Ring Transformation to 2-(Aminomethyl)-1-aminocyclopropanecarboxylic Acid Derivatives
Yazarlar dc.contributor.author	Nural, Yahya
Kurum Dışı Yazarlar dc.contributor.other	De Brabandere, Stijn
Kurum Dışı Yazarlar dc.contributor.other	Mangelinckx, Sven
Kurum Dışı Yazarlar dc.contributor.other	Kadam, Santosh T.
Kurum Dışı Yazarlar dc.contributor.other	Augustyns, Koen
Kurum Dışı Yazarlar dc.contributor.other	Van der Veken, Pieter
Kurum Dışı Yazarlar dc.contributor.other	Tornroos, Karl W.
Kurum Dışı Yazarlar dc.contributor.other	De Kimpe, Norbert
Yayıncı dc.publisher	WILEY-V C H VERLAG GMBH
Yayın Türü dc.type	Makale
Özet dc.description.abstract	1-Benzyl-2-(bromomethyl)aziridine was successfully substituted with protected glycine esters to afford alkyl 3-(N-benzylaziridin-2-yl)-2-aminopropanoates, as constrained heterocyclic diamino acid derivatives, in good isolated yields. These new aziridines proved to be excellent building blocks for ring transformation to the corresponding stereochemically defined 2-(aminomethyl)-1-aminocyclopropanecarboxylic acid derivatives, including methyl esters, piperidyl amides, and free carboxylic acids.
Kayıt Giriş Tarihi dc.date.accessioned	2025-12-26
Yayın Yılı dc.date.issued	2014
Açık Erișim Tarihi dc.date.available	2099-01-01
Dil dc.language.iso	eng
Konu Başlıkları dc.subject	α-Amino Acid
Konu Başlıkları dc.subject	2-(Aminomethyl)-1-aminocyclopropanecarboxylic Acid Derivatives
Atıf İçin Künye dc.identifier.citation	De Brabandere, S., Mangelinckx, S., Kadam, S. T., Nural, Y., Augustyns, K., Van der Veken, P., ... & De Kimpe, N. (2014). Synthesis of γ, δ‐Aziridino α‐Amino Acid Derivatives and their Stereoselective Ring Transformation to 2‐(Aminomethyl)‐1‐aminocyclopropanecarboxylic Acid Derivatives. European Journal of Organic Chemistry, 2014(6), 1220-1226.
ISSN dc.identifier.issn	1434-193X
İlk Sayfa dc.identifier.startpage	1220
Son Sayfa dc.identifier.endpage	1226
Makale Numarası dc.identifier.articlenumber	-
Dergi Adı dc.relation.journal	EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Dergi Sayısı dc.identifier.issue	6
Dergi Cilt dc.identifier.volume	2014
Tek Biçim Adres (URI) dc.identifier.uri	https://doi.org/10.1002/ejoc.201301030
Tek Biçim Adres (URI) dc.identifier.uri	https://hdl.handle.net/20.500.14114/8688
DOI Numarası dc.identifier.doi	10.1002/ejoc.201301030
İndekslenen Platformlar dc.source.database	Web of Science

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