Physicochemical parameters provide critical information for scientists in the many scientific fields such
as drug research studies, the development of analysis methods, etc [1]. The acid dissociation constant
(pKa) is one of the most important physicochemical parameters [1-3]. In this study [4], acid dissociation
constants of the potential bioactive 2-(pyrrolidin-1-yl)thiazole derivatives were potentiometrically
determined at 25.0 ± 0.1 ºC in a 30% (v/v) DMSO-water mixture. The potentiometrically obtained data
were used for the calculation of the pKa values using the HYPERQUAD computer program. Three
different pKa values were found for the compounds and the pKa1, pKa2 and pKa3 values were obtained in a
range of 2.46 (±0.10) - 3.78 (±0.10), 5.61 (±0.07) - 6.77 (±0.08) and 8.50 (±0.03) - 10.21 (±0.03),
respectively. According to these obtained results, we propose that the calculated pKa1, pKa2 and pKa3
values are related to NH, SH and OH groups, respectively.