Background: In order to ensure the early treatment of crush syndrome in emergencydepartments in times of disaster, there is a need for tools that will accelerate andfacilitate the diagnosis. We aimed to assess hematologic inflammatory markers aspotential diagnostic indicators of crush syndrome in pediatric patients injured bybeing trapped under debris in the 2023 Turkey–Syria earthquake.Methods: This analytical study included 123 pediatric cases with a history of beingunder debris. Patients were divided into three groups according to serum creatinekinase (CK) values and clinical characteristics at the time of admission: traumagroup with a normal CK level (n = 33), crush injury group (n = 30), and crush syndromegroup (n = 64). Complete blood count results sent at the time of presentation to theemergency department were analyzed. The neutrophil-to-lymphocyte ratio (NLR),platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR),systemic immune-inflammation index (SII), systemic inflammatory response index(SIRI), and the aggregate index of systemic inflammation (AISI) were calculated.Results: The median NLR, MLR, SII, SIRI, and AISI were significantly higherin the crush syndrome group compared to both the normal CK and crush injurygroups (p < 0.001). According to receiver operating characteristic curve analysisperformed for distinguishing between patients with and without crush syndrome,the area under curves of NLR, MLR, PLR, SII, SIRI, and AISI were 0.75, 0.72,0.63, 0.73, 0.75, and 0.72, respectively.Conclusions: The use of hematologic inflammatory markers may assist clinicians inmaking rapid decisions regarding the diagnosis and treatment of crush syndromein the event of a disaster